DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lasp and abp1

DIOPT Version :9

Sequence 1:	NP_730192.2	Gene:	Lasp / 39864	FlyBaseID:	FBgn0063485	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_594921.1	Gene:	abp1 / 2542979	PomBaseID:	SPAPJ760.02c	Length:	857	Species:	Schizosaccharomyces pombe

Alignment Length:	695	Identity:	132/695 - (18%)
Similarity:	221/695 - (31%)	Gaps:	173/695 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GYNKMPYCEAHIPKAKATAIADT----PELKRIAENTKIQSNVKYHADFEKAKGKFTQVA----D 102
            |.:|....|:|.| ||..::..:    |.:......:..:|....||.......|.|.:.    .
pombe   249 GPSKPTPFESHGP-AKQISVQPSEHPKPSISTTTTGSSYRSAESSHAPTTPDHFKLTPLTKLEPQ 312

  Fly   103 DPETLRIKQNTKHISNVAYHGDLE---KKAAMEKQRGSAEVSDSSNESEYFSEQLAAEQFSQYAP 164
            .|.....|:....:..:...|::.   ::|..||:.     |.:.|.....|..|.       :|
pombe   313 PPSGSPSKKPVSELEELHTAGNVNLSARRALFEKKE-----SSTKNVENPVSHHLK-------SP 365

  Fly   165 TASPIPPAATTLHQQ---------QQQLQHQQQQQYQQHQQQLQQQQHQHQHYLQ---------- 210
            ..:..|||:||..:|         :|:......:|...::...|::..:....|:
pombe   366 VRTSFPPASTTASKQDSPSTVPVDKQETAKPINKQVSSNETSAQEEPRESVAALRARFAKANVSE 430

  Fly   211 -QQQQTLPPPPIQHQQYNTAAIT------PTYQQLQQQQQQQQQQRAQQQQLHDPYAHYQQPQAL 268
             ....|.|....:...:|:.|.|      |...........::....:...|:.|.|   .|:..
pombe   431 NNDPPTFPKTAAKISSFNSKAGTSFAKPRPFTNNPNPISAPEKPTSGESLSLNPPPA---MPKVF 492

  Fly   269 --RQQQQQQQQQQQQLLQQQAIKQ--ASHLYPTATSQQQQMPP--------------------PQ 309
              |......|:..|..:...::.|  |:.:.|.|.|..|  ||                    |:
pombe   493 PERDISSASQKAAQPSVITPSVPQPPAAPVVPEAPSVHQ--PPAAPVAPEVPSAPQRPAAPVVPE 555

  Fly   310 SPANPQQQALNSYNEMRSAILQNSHHPSGNSVDQYDQPQQQQHQPQQQSTNPTLVAAQQQQSHHS 374
            :|:.||:.|:....|..| :.|....|....|....||......|:..|.....||....:
pombe   556 APSVPQRPAVPVVPEALS-VPQPPVAPVAPEVPSVPQPPVAPVVPEAPSVPQPPVAPVAPE---- 615

  Fly   375 LLNNNASNGGISHSHHSNINNNGHGSQNQMLPPQMRRSAASVVAYDGNSKQQVAAG-----PGAA 434
                                          :|...:|.|..||....:..|..||.     |...
pombe   616 ------------------------------VPSVPQRPAVPVVPEAPSVPQPPAAPVVPEVPSVP 650

  Fly   435 QN----------HLQQLYASPNYAAV--TPSENSINVKQHASNGHMP--------NQQQQHVAGG 479
            |.          .:.|..|:|....|  .|...::.|...|...:.|        ::.|:...||
pombe   651 QRPAVPVVPEAPSVPQPPAAPVVPEVPSVPQPPAVPVVPEAGQLNEPVVPPLPPHDETQEPQVGG 715

  Fly   480 SNIGKIADYDPLTDGPRVVPNAGRSSTTLVYSSEPRGNQGGNSVYPKRIGSVSDIDPANGIYGSL 544
            .  .|..::...|..|.:|          :|...|........|..::|..:..:|.     |..
pombe   716 D--VKATEHTQPTKTPAIV----------IYDYSPEEENEIELVENEQIQILEFVDD-----GWW 763

  Fly   545 TAAEQAHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSYSSLQEKQSRQSTAMRVYRAIYDYEA 609
            .......||......|.::....:..:.|..:.....|..|               .:|||||:|
pombe   764 LGENSKGQQGLFPSNYVEITGPNETANNPPAEPQAGGPGKS---------------VKAIYDYQA 813

  Fly   610 QDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPANYVEQ 654
            |:.:|:||.|.::|..|:.:|..|..|  |..|..|:.|:||||:
pombe   814 QEDNELSFFEDEIIANVDCVDPNWWEG--ECHGHRGLFPSNYVEE 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	3/10 (30%)
		Nebulin	68..94	CDD:279252	4/29 (14%)
		NEBU	97..127	CDD:128523	4/36 (11%)
		SH3_Nebulin_family_C	600..654	CDD:212723	23/53 (43%)
abp1	NP_594921.1	ADF_drebrin_like	5..138	CDD:200437
		SH3	729..782	CDD:302595	11/67 (16%)
		SH3_Abp1_fungi_C2	804..856	CDD:212894	24/68 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R73
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030