DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lasp and NEBL

DIOPT Version :10

Sequence 1:NP_730192.2 Gene:Lasp / 39864 FlyBaseID:FBgn0063485 Length:657 Species:Drosophila melanogaster
Sequence 2:NP_006384.1 Gene:NEBL / 10529 HGNCID:16932 Length:1014 Species:Homo sapiens


Alignment Length:653 Identity:142/653 - (21%)
Similarity:240/653 - (36%) Gaps:198/653 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 MKTYKGYNKMPYCEAHIPKAKATAIA-DTPELKRIAENTKIQSNVKYHADFEKAKGKFTQVADDP 104
            |.:.|.|.|  ..|..| |.|...:: |.|::.|....::|.|..||..:.||....::.:||.|
Human   517 MASQKQYKK--DLENEI-KGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTP 578

  Fly   105 ETLRIKQNTKHISNVAYHGDLEKKAAMEKQRGSAEVSDSSNESEYFSEQLAAEQFSQYAPTASPI 169
            |..|||...::||.|.|..::....|:   :.|.|:.......:..|.....|:...  .||...
Human   579 EIQRIKTTQQNISAVFYKKEVGAGTAV---KDSPEIERVKKNQQNISSVKYKEEIKH--ATAISD 638

  Fly   170 PPAATTLHQQQQQLQHQQQQQYQQHQQQLQQQQHQHQHYLQQQQQTLPPPPIQHQQYNTAAITPT 234
            ||               :.::.:::|:.:...|::.|:|                :....::||.
Human   639 PP---------------ELKRVKENQKNISNLQYKEQNY----------------KATPVSMTPE 672

  Fly   235 YQQLQQQQQQQQ--QQRAQQQQ---LHDPYAHYQQPQALRQQQQQQQQQQQQLLQQQAIKQASHL 294
            .:::::.|:|..  :.:.:.|:   :.||      |:..|.::.|              |..|::
Human   673 IERVRRNQEQLSAVKYKGELQRGTAISDP------PELKRAKENQ--------------KNISNV 717

  Fly   295 Y-----PTATSQQQQMPPPQSPANPQQQALNSYNEMRSAILQNSHHPSGNSVDQYDQPQQQQHQP 354
            |     ..||:..         ..|:.:.:....|..|::.....|            :|.:.:|
Human   718 YYRGQLGRATTLS---------VTPEMERVKKNQENISSVKYTQDH------------KQMKGRP 761

  Fly   355 QQQSTNPTLVAAQQQQSHHSLLNNNASNGGISHSHHSNI-NNNGHGSQNQMLPPQMRR-----SA 413
            ......|.:...::.|:|.|::           .:|.:. ...|.|....:..|...|     ..
Human   762 SLILDTPAMRHVKEAQNHISMV-----------KYHEDFEKTKGRGFTPVVDDPVTERVRKNTQV 815

  Fly   414 ASVVAYDGNSKQQVAAGPGAAQNHLQQLYASPNYAAVTPSENSINVKQHASNGHMPNQQQQHVAG 478
            .|..||.|            ...|:.::...|...        :::|                ..
Human   816 VSDAAYKG------------VHPHIVEMDRRPGII--------VDLK----------------VW 844

  Fly   479 GSNIGKIADYDPLTDGPRVVPNAGRSSTTLVYSSEPRGN-------QGGNSVYPKRIG----SVS 532
            .::.|.|.|.|||.|..:        |.:|...||...:       ...:|.:...:|    .:|
Human   845 RTDPGSIFDLDPLEDNIQ--------SRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEIS 901

  Fly   533 DIDPANGIYGSLT------------AAEQAHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSYS 585
            :|.|:......:|            |.:|:|.|.....:...|..|:..:|.|.           
Human   902 EIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPN----------- 955

  Fly   586 SLQEKQSRQSTAMRVYRAIYDYEAQDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPAN 650
                        :|.|||:|||.|||.||||||:||.|..|:.||.|||.|.|:|||:|||||||
Human   956 ------------LRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPAN 1008

  Fly   651 YVE 653
            |:|
Human  1009 YIE 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LaspNP_730192.2 LIM_LASP 5..57 CDD:188831 5/15 (33%)
Nebulin 67..94 CDD:459977 9/26 (35%)
NEBU 97..127 CDD:128523 11/29 (38%)
SH3_Nebulin_family_C 600..654 CDD:212723 38/54 (70%)
NEBLNP_006384.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Nebulin 1 29..63
NEBU 30..60 CDD:128523
Nebulin 2 64..99
Nebulin 3 100..136
Nebulin 4 137..172
Nebulin 5 173..205
Nebulin 6 206..241
Nebulin 7 242..278
Nebulin 8 279..313
PTZ00121 <294..712 CDD:173412 51/253 (20%)
Nebulin 9 314..348
Nebulin 320..347 CDD:459977
Nebulin 10 349..385
Nebulin 11 386..422
Nebulin 12 423..459
Nebulin 13 460..496
Nebulin 14 497..533 6/18 (33%)
Nebulin 15 534..569 10/34 (29%)
Nebulin 16 570..599 11/28 (39%)
Nebulin 17 600..635 5/39 (13%)
NEBU 603..632 CDD:128523 5/31 (16%)
Nebulin 18 636..666 6/60 (10%)
Nebulin 19 667..693 4/25 (16%)
Nebulin 20 694..728 9/53 (17%)
Nebulin 21 729..759 5/50 (10%)
Nebulin 732..758 CDD:459977 5/37 (14%)
Nebulin 22 760..794 6/44 (14%)
Nebulin 766..793 CDD:459977 5/37 (14%)
Nebulin 23 795..830 8/46 (17%)
Linker 836..953 24/148 (16%)
SH3_Nebulette_C 957..1014 CDD:212868 39/55 (71%)
Blue background indicates that the domain is not in the aligned region.

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