DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lasp and NEBL

DIOPT Version :9

Sequence 1:	NP_730192.2	Gene:	Lasp / 39864	FlyBaseID:	FBgn0063485	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_006384.1	Gene:	NEBL / 10529	HGNCID:	16932	Length:	1014	Species:	Homo sapiens

Alignment Length:	653	Identity:	142/653 - (21%)
Similarity:	240/653 - (36%)	Gaps:	198/653 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MKTYKGYNKMPYCEAHIPKAKATAIA-DTPELKRIAENTKIQSNVKYHADFEKAKGKFTQVADDP 104
            |.:.|.|.|  ..|..| |.|...:: |.|::.|....::|.|..||..:.||....::.:||.|
Human   517 MASQKQYKK--DLENEI-KGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTP 578

  Fly   105 ETLRIKQNTKHISNVAYHGDLEKKAAMEKQRGSAEVSDSSNESEYFSEQLAAEQFSQYAPTASPI 169
            |..|||...::||.|.|..::....|:   :.|.|:.......:..|.....|:...  .||...
Human   579 EIQRIKTTQQNISAVFYKKEVGAGTAV---KDSPEIERVKKNQQNISSVKYKEEIKH--ATAISD 638

  Fly   170 PPAATTLHQQQQQLQHQQQQQYQQHQQQLQQQQHQHQHYLQQQQQTLPPPPIQHQQYNTAAITPT 234
            ||               :.::.:::|:.:...|::.|:|                :....::||.
Human   639 PP---------------ELKRVKENQKNISNLQYKEQNY----------------KATPVSMTPE 672

  Fly   235 YQQLQQQQQQQQ--QQRAQQQQ---LHDPYAHYQQPQALRQQQQQQQQQQQQLLQQQAIKQASHL 294
            .:::::.|:|..  :.:.:.|:   :.||      |:..|.::.|              |..|::
Human   673 IERVRRNQEQLSAVKYKGELQRGTAISDP------PELKRAKENQ--------------KNISNV 717

  Fly   295 Y-----PTATSQQQQMPPPQSPANPQQQALNSYNEMRSAILQNSHHPSGNSVDQYDQPQQQQHQP 354
            |     ..||:..         ..|:.:.:....|..|::.....|            :|.:.:|
Human   718 YYRGQLGRATTLS---------VTPEMERVKKNQENISSVKYTQDH------------KQMKGRP 761

  Fly   355 QQQSTNPTLVAAQQQQSHHSLLNNNASNGGISHSHHSNI-NNNGHGSQNQMLPPQMRR-----SA 413
            ......|.:...::.|:|.|::           .:|.:. ...|.|....:..|...|     ..
Human   762 SLILDTPAMRHVKEAQNHISMV-----------KYHEDFEKTKGRGFTPVVDDPVTERVRKNTQV 815

  Fly   414 ASVVAYDGNSKQQVAAGPGAAQNHLQQLYASPNYAAVTPSENSINVKQHASNGHMPNQQQQHVAG 478
            .|..||.|            ...|:.::...|...        :::|                ..
Human   816 VSDAAYKG------------VHPHIVEMDRRPGII--------VDLK----------------VW 844

  Fly   479 GSNIGKIADYDPLTDGPRVVPNAGRSSTTLVYSSEPRGN-------QGGNSVYPKRIG----SVS 532
            .::.|.|.|.|||.|..:        |.:|...||...:       ...:|.:...:|    .:|
Human   845 RTDPGSIFDLDPLEDNIQ--------SRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEIS 901

  Fly   533 DIDPANGIYGSLT------------AAEQAHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSYS 585
            :|.|:......:|            |.:|:|.|.....:...|..|:..:|.|.
Human   902 EIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPN----------- 955

  Fly   586 SLQEKQSRQSTAMRVYRAIYDYEAQDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPAN 650
                        :|.|||:|||.|||.||||||:||.|..|:.||.|||.|.|:|||:|||||||
Human   956 ------------LRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPAN 1008

  Fly   651 YVE 653
            |:|
Human  1009 YIE 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	5/15 (33%)
		Nebulin	68..94	CDD:279252	8/25 (32%)
		NEBU	97..127	CDD:128523	11/29 (38%)
		SH3_Nebulin_family_C	600..654	CDD:212723	38/54 (70%)
NEBL	NP_006384.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Nebulin 1	29..63
		NEBU	30..60	CDD:128523
		Nebulin 2	64..99
		Nebulin 3	100..136
		Nebulin 4	137..172
		Nebulin 5	173..205
		Nebulin 6	206..241
		Nebulin 7	242..278
		Nebulin 8	279..313
		Neuromodulin_N	<294..712	CDD:331332	51/253 (20%)
		Nebulin 9	314..348
		Nebulin 10	349..385
		Nebulin 11	386..422
		Nebulin 12	423..459
		Nebulin 13	460..496
		Nebulin 14	497..533		6/18 (33%)
		Nebulin 15	534..569		10/34 (29%)
		Nebulin 16	570..599		11/28 (39%)
		Nebulin 17	600..635		5/39 (13%)
		Nebulin 18	636..666		6/60 (10%)
		Nebulin 19	667..693		4/25 (16%)
		Nebulin 20	694..728		9/53 (17%)
		NEBU	727..756	CDD:128523	5/49 (10%)
		Nebulin 21	729..759		5/50 (10%)
		Nebulin 22	760..794		6/44 (14%)
		NEBU	762..791	CDD:128523	5/39 (13%)
		Nebulin 23	795..830		8/46 (17%)
		Linker	836..953		24/148 (16%)
		SH3_Nebulette_C	957..1014	CDD:212868	39/55 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9133
eggNOG	1	0.900	-	-		E1_KOG1702
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.770