DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13032 and ccdc13

DIOPT Version :9

Sequence 1:	NP_648911.1	Gene:	CG13032 / 39863	FlyBaseID:	FBgn0036652	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_009294898.1	Gene:	ccdc13 / 555345	ZFINID:	ZDB-GENE-061207-11	Length:	666	Species:	Danio rerio

Alignment Length:	645	Identity:	165/645 - (25%)
Similarity:	277/645 - (42%)	Gaps:	141/645 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ESKKLRKKLSECEQEKQSLAQAIHEKNQEISDLKKSVDSLNEVLNSVPIDELRCNSS------IA 112
            |:::|...:.|...|...|.:.:.||:.||..|||..:.          |.|....:      .|
Zfish    77 ENEQLLDHVRELRDENGRLHKLLSEKDFEIKHLKKKREE----------DRLALAGTAGLAGDAA 131

  Fly   113 STKILELSKKNRQMRSELEQAKSRLGKKDAQIEKLEKELRA--------HEEKLQHNQ---DLPK 166
            :|||:|||||.|.:.||:|:.|::..:.:.::.:|||||:|        ...|.|.::   |.|:
Zfish   132 ATKIVELSKKTRDLASEVEREKTKTKQANNRVRELEKELQAMLLLNPGKTTNKKQASKIVDDHPE 196

  Fly   167 KGCSPDELQAKINSMQQKLFETRNRNTELQSQLKLAQKCLQHEIGESCNI-NILANNLNQANWRG 230
            .......||.|::..|.|:.|.||:....:.:||:|.|.|..|:||..:| .||.   |...|||
Zfish   197 NNPVVKSLQEKLSVAQLKMAEYRNQIQTFKQELKIAHKVLSCEVGEDVSIQQILC---NPGGWRG 258

  Fly   231 RAQQIIALNQKVHELKARLDFYEDRAVDRAEYAAPVPLGSDLELVTGSCRSHHASSERLGGGD-- 293
            |:|||:||..:|.:|:.:|                            |..||.......|..|
Zfish   259 RSQQILALQNRVRDLEQQL----------------------------SQSSHRKPLNEFGLEDEM 295

  Fly   294 ---GGGATTASFDRFTPGVRKSEILHRAKVEALEKEILSLQNQLE---DQRSKTLALKVRNKNLN 352
               ||...|.  ||....:|..|   :.|.|.|||..:..:..||   |.:.|....|.|||.|:
Zfish   296 MRTGGPMKTQ--DRNLSHIRHIE---KEKKETLEKLTVEYEVLLEEHTDVKKKLEGSKARNKVLS 355

  Fly   353 EEMNKYKILYNELEEQTDFNGTNINTMNDKLNQQRIQYENRLDDMRGELVRVTEERDLSRRQMEE 417
            .|:   |.|.:::....| .|.:.:.:.|.|.:|:.|::    .|.|.|.....:|:.|::.:|
Zfish   356 TEI---KALKSQIGTLLD-KGKHDDELVDALLKQQTQWQ----VMLGRLSLKGSQREESQQGLE- 411

  Fly   418 LSGMHLELQ---TVVKQKDVAMASLQDMIKKLEMDLRAL------------SGGFLFSCREFRKE 467
             :.:|.|:|   ::::|..:.:|..::.:|:||.::|.|            :...|.|.:|..:|
Zfish   412 -THLHSEVQQHSSLIQQLKLMVAEKENKVKELEQEIRQLALTKQSESKSLQNSRSLTSQQEKSRE 475

  Fly   468 --------------------------EFVGILDALEVEKNQLMLLTKTLGDRLETERAKNEAAQE 506
                                      |:..:..:..||:::|:.|||       .:.|:.|.|:.
Zfish   476 ANPARDALVACPECAVKVPSLQAQCAEYKTLYQSASVERDRLLELTK-------VQHAREEEAKR 533

  Fly   507 QIGKLKARISRLEVKIRDLEKELD-VQSDKKKRTQRMADYASSLSRTSLNGSIGSF--CFENQSQ 568
            |..:.:.::.:...:...||::|: .:.|.||.....   .|..|||..:|||.|.  ..|..|.
Zfish   534 QCAEAEQKLRQEWQRSVSLEQQLEKAKLDAKKEASLQ---TSHRSRTGSSGSILSLPERLEGLSP 595

  Fly   569 YQSTNTLNSAGQPEPRIEDLKNNLELAKEKITMLTEKLEYITEEKNADAKFFEDTINSTK 628
            ...::....|     ::.:||..|.|..|:...|...|....:||....:|::|.:...|
Zfish   596 RSPSDISRDA-----QLSELKAQLALQLEENETLRTTLRNTLKEKKEVLQFYKDMMTEAK 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13032	NP_648911.1	Smc	<52..647	CDD:224117	165/645 (26%)
ccdc13	XP_009294898.1	SMC_prok_B	<329..>557	CDD:274008	51/244 (21%)
ccdc13	XP_009294898.1	COG4913	<491..>632	CDD:227250	35/155 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576699
Domainoid	1	1.000	121	1.000	Domainoid score	I5630
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4726
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1533296at2759
OrthoFinder	1	1.000	-	-		FOG0009373
OrthoInspector	1	1.000	-	-		oto39470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31935
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.030