DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13032 and ccdc13

DIOPT Version :9

Sequence 1:	NP_648911.1	Gene:	CG13032 / 39863	FlyBaseID:	FBgn0036652	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	XP_004915640.1	Gene:	ccdc13 / 100489430	XenbaseID:	XB-GENE-992948	Length:	705	Species:	Xenopus tropicalis

Alignment Length:	736	Identity:	167/736 - (22%)
Similarity:	303/736 - (41%)	Gaps:	180/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ETLPEEYVAHRDQELLG-------CKVGRSSRRRHDHDAMAAAHVVLTTAVVKPKPTKPESKKLR 59
            |..|::....|..|..|       .:.|.||                 |:.:..:..:.|:.:|:
Frog    38 EEQPQQQERSRSSEAFGVQDQLHLLRPGGSS-----------------TSDIGKRLLEDENDQLQ 85

  Fly    60 KKLSECEQEKQSLAQAIHEKNQEISDLKKSVDSLNEVLNSVPIDELRCNSSIASTKILELSKKNR 124
            .::.|.:.|...|.:.:.||..||..|:|.::.....|...    ......:|:|||:|||||||
Frog    86 DQIRELKDENGRLHKLVQEKEFEIRHLRKKLEEGKLALAGT----AGLAGDVAATKIVELSKKNR 146

  Fly   125 QMRSELEQAKSRLGKKDAQIEKLEKELR-------AHEEKLQHNQDLPKKGC---SPD--ELQAK 177
            ::.:|||..::::.:.:.:::.:||||:       ..|....|::.....|.   ||:  .||.|
Frog   147 ELTAELESERTKVKQLNNRVKGVEKELQNLAVNYTGKESGNGHSRTQIADGTPAESPELKALQEK 211

  Fly   178 INSMQQKLFETRNRNTELQSQLKLAQKCLQHEIGESCNINILANNLNQANWRGRAQQIIALNQKV 242
            :.:...|:.|.||:...::.:||:|.|.|..|:||..||:.||  .:..:||||||||:||..:|
Frog   212 LAATNLKMIEYRNQIQSMKQELKVAHKVLVSEVGEEVNISQLA--ASSGSWRGRAQQILALQGRV 274

  Fly   243 HELKARLDFYEDRAVDRAEYAAPVPLGSDLELVTGSCRSHHASSERLGGGDGGGATTASFDRFTP 307
            .||:.:|          .:..:||   |:|.|           .|.|.|........|.    ..
Frog   275 RELENQL----------GQGRSPV---SELSL-----------EEELSGVTVPKRVAAQ----EK 311

  Fly   308 GVRKSEILHRAKVEALEK---EILSLQNQLEDQRSKTLALKVRNKNLNEEMNKYKILYNELEEQT 369
            .:.:...|.:.:.|||||   |..:.:...||.:.|..|.|.||..|:.|:...|:....:.|:
Frog   312 NLFRIRTLEKERKEALEKITAEYEAFKKDNEDLKKKLEASKARNTVLSNEVKMLKMQMATILEK- 375

  Fly   370 DFNGTNINTMNDK-LNQQRIQYENRLDDMRGELVRVTEERDLSRRQMEEL-----------SGMH 422
               |.:.|.:.|. |:||:        :|:..|.|::::...::...:.|           |.:.
Frog   376 ---GKHDNELIDALLSQQK--------NMQEVLTRLSQQEQKNKDSQQNLNMQCNSEAQKQSSLV 429

  Fly   423 LELQTVVKQKDVAMASLQDMIKKLEM--DLRALSGGFLFSCREF--------------------- 464
            .:|:.:|.:::..:..|:|.||:|.:  ..|..|.|.:...:||
Frog   430 SQLKYMVAEREAKVKELEDEIKQLTLKNHHRKESSGKILDVQEFPSVAKSEKLSPIRSLSDSGDQ 494

  Fly   465 ---------------------------------------RKEEFVGILDALEVEKNQLMLLTKTL 490
                                                   :..|:..:..|.|||:::||.|...|
Frog   495 PWSGSRTVSKLGHELIQAQSPNGNISASPRSSEVRVLQAQVTEYRTLCQAAEVERDRLMELVSVL 559

  Fly   491 GDRLETERAKNEAAQEQIGKLKARISRLEVKIRDLEKELDVQSDKKKRTQRM-----ADYASSLS 550
            ..|:|....|...|::::.:.:.|...||.:    .:.|.:.:.|...||::     |..:.|:|
Frog   560 QKRVEESNEKLLGAEKRLQEERRRCVLLEQQ----AERLKMDTAKNVGTQKLSARGKAGPSLSIS 620

  Fly   551 RTSLNGSIGSFCFENQSQYQSTNTLNSAGQP-EPRIEDLKNNLELAKEKITMLTEKLEYITEEKN 614
            |.|:|       |..:::.    :...|..| |.:||:|:..|.:..::...:...|:...:.|.
Frog   621 RHSVN-------FNGKTEV----SFAPADLPLETQIEELRTQLAIQMDENEAIKTSLKSTLKTKE 674

  Fly   615 ADAKFFEDTINSTKTIILETV 635
            .|.|.:.:.:...|.|.::.:
Frog   675 DDLKLYHEMMGEVKQIFIQAL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13032	NP_648911.1	Smc	<52..647	CDD:224117	158/679 (23%)
ccdc13	XP_004915640.1	SMC_prok_B	<102..453	CDD:274008	107/396 (27%)
ccdc13	XP_004915640.1	CALCOCO1	<321..>595	CDD:285171	56/289 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1533296at2759
OrthoFinder	1	1.000	-	-		FOG0009373
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31935
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.140