DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and GNA14

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_004288.1	Gene:	GNA14 / 9630	HGNCID:	4382	Length:	355	Species:	Homo sapiens

Alignment Length:	377	Identity:	133/377 - (35%)
Similarity:	205/377 - (54%)	Gaps:	35/377 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KEDQ-YPVSLDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPE 86
            ||.| ....::..:.:|.....|:  :|:|||||.||||:|.||||||:|.:|::|::|:.....
Human    12 KESQRISAEIERQLRRDKKDARRE--LKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFTKL 74

  Fly    87 IYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPEYMNEEYCDHVTTLWNDVGIRA 151
            :||||..::..::..|..|.|.:....::.:|..|..:.......::.|..:.:..||.|.||:.
Human    75 VYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSMLSREQVEAIKQLWQDPGIQE 139

  Fly   152 CYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGISQITFRVPIPKSMGGGEQQ 216
            ||||..|:.|.|||||:|.:..||:...::|:.:|:|..|..||||.:..|.:.        ...
Human   140 CYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLE--------NII 196

  Fly   217 FQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLA 281
            |:|.||||||.:|.|||..||.:.:::||::.||:||.|.|..::||::|:..||:.:....:..
Human   197 FRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFL 261

  Fly   282 SAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQEP 346
            ::.:|:||||.|::|.||.. .|::.|||||..    |:||     ....:.||.:...|  |.|
Human   262 NSSVILFLNKKDLLEEKIMY-SHLISYFPEYTG----PKQD-----VRAARDFILKLYQD--QNP 314

  Fly   347 FKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGL 398
            .|            |:..|.|||.||||..||.||..|:..||..|:....|
Human   315 DK------------EKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLREFNL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	129/366 (35%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	126/343 (37%)
GNA14	NP_004288.1	G_alpha	16..353	CDD:214595	129/370 (35%)
		G-alpha	36..349	CDD:206639	126/344 (37%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	37..50		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750