DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galphaf and gnav1

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001159486.1	Gene:	gnav1 / 571305	ZFINID:	ZDB-GENE-081031-92	Length:	362	Species:	Danio rerio

Alignment Length:	384	Identity:	136/384 - (35%)
Similarity:	205/384 - (53%)	Gaps:	36/384 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 MTHKEDQYPVSLDHHVLKDMAKGVRD--TTVKILLLGTAESGKTTIIKQMRILHINGFTDDERRE 82
            :|.:||:........:.:|:.:..:.  ..|||||||.|||||:|::|||:|:|.:|||..|...
Zfish     9 VTTEEDKKAKIHSSQIDRDLYEYAKRELNVVKILLLGAAESGKSTLVKQMKIIHSHGFTKQELTS 73

  Fly    83 KIPEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE-YMNEEYCDH-VTTLWN 145
            ..|.:..|:..|:..::..||||.|:..:..::..|..:||......| .|...:..| :..||.
Zfish    74 FKPAVLDNLLTSMKFVLHGMGVLRINLANPKNKVHAHSVLSCGRCFDEDQMLFPFIAHALCCLWA 138

  Fly   146 DVGIRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGISQITFRVPIPKSM 210
            |.|:|:...|..|:.|.|||.||.:|..||...:|:|:..|:|..|..|||:.:..|:|.
Zfish   139 DPGVRSSAARGYEYELNDSALYFFENMGRIIADDYMPTETDVLRVRLRTTGVIETQFKVK----- 198

  Fly   211 GGGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVW 275
               ...|:||||||||.:|.|||..||.:::|||::|.|.:|..|.||||.|||||:||||.::.
Zfish   199 ---HLVFRMYDVGGQRTERRKWISCFEYVRSVLFVVSLSGYDMTLVEDPSMNRLQESLKLFSSIC 260

  Fly   276 QNRFLASAGLIVFLNKYDIMERKI-RAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKL 339
            .|.|.....:|:|:||.|:.:.|| .:|:|:..|.|::       :..:|  :.|....||....
Zfish   261 NNIFFRGTSMILFMNKIDLFQEKILHSGRHLRHYLPQF-------RGADC--DVDAAARFIADMF 316

  Fly   340 VDITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGL 398
            |.:...|.|.              .|:|||.||||..::.||..|...|:.||:.::.|
Zfish   317 VSLNASPSKL--------------IYHHFTTATDTSNVQVVFQVVMDTIIKENLEAVSL 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	132/371 (36%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	129/346 (37%)
gnav1	NP_001159486.1	G_alpha	20..357	CDD:214595	132/367 (36%)
gnav1	NP_001159486.1	G-alpha	39..356	CDD:206639	130/347 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750