DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and gna11b

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001007774.1	Gene:	gna11b / 493613	ZFINID:	ZDB-GENE-041121-9	Length:	359	Species:	Danio rerio

Alignment Length:	394	Identity:	135/394 - (34%)
Similarity:	216/394 - (54%)	Gaps:	41/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLRCLRQQPAKPAAVMTHKEDQYPVSLDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRI 69
            ::.|...:.||       :..:....:|..:.:|.....|:  :|:|||||.||||:|.||||||
Zfish     6 MMACCLSEEAK-------ESKRINAEIDKQLRRDKRDARRE--LKLLLLGTGESGKSTFIKQMRI 61

  Fly    70 LHINGFTDDERREKIPEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPEYMNE 134
            :|..|:||:::|.....:||||..|:..::.....|.|.:....::.:|..:..:........:.
Zfish    62 IHGAGYTDEDKRGFTKLVYQNIFTSMQAMIRATETLKIGYKYEQNKANAMLVKEVDIEKVMSFDH 126

  Fly   135 EYCDHVTTLWNDVGIRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGISQ 199
            .|.:.|..||:|.||:..|||..|:.|.||.||:|.:..||:::.|:|:.:|:|..|..||||.:
Zfish   127 PYINAVKMLWSDPGIQEAYDRRREYQLSDSTKYYLSDLDRIAESSYLPTQQDVLRVRIPTTGIIE 191

  Fly   200 ITFRVPIPKSMGGGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRL 264
            ..|.:   :|:     .|:|.||||||.:|.|||..||.:.:::||::.||:||.|.|..::||:
Zfish   192 YPFDL---QSI-----IFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRM 248

  Fly   265 QEALKLFRAVWQNRFLASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESD 329
            :|:..|||.:....:..::.:|:||||.|::|.|| :..|:||||||::.    ||:|     :.
Zfish   249 EESKALFRTIITYPWFQNSSVILFLNKKDLLEEKI-SYSHLVDYFPEFDG----PQRD-----AQ 303

  Fly   330 WTKMFIKQKLVDITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVS 394
            ..:.||.:..||:..:              |::..|.|||.||||..||.||..|:..||..|:.
Zfish   304 AAREFILKMFVDLNPD--------------SDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLK 354

  Fly   395 SMGL 398
            ...|
Zfish   355 EYNL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	131/366 (36%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	127/343 (37%)
gna11b	NP_001007774.1	G_alpha	19..357	CDD:214595	131/371 (35%)
gna11b	NP_001007774.1	G-alpha	40..353	CDD:206639	127/344 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820