DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and GNAT2

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001364224.1	Gene:	GNAT2 / 2780	HGNCID:	4394	Length:	354	Species:	Homo sapiens

Alignment Length:	370	Identity:	135/370 - (36%)
Similarity:	211/370 - (57%)	Gaps:	39/370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KDMAKGVRD------TTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIYQNIHESI 95
            |::.|.:::      .|||:||||..||||:||:|||:|:|.:|::.:|..|....||.|:.:||
Human    17 KELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECLEFKAIIYGNVLQSI 81

  Fly    96 LQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE-YMNEEYCDHVTTLWNDVGIRACYDRSNEF 159
            |.::..|..||||:...:.......:.:|..|..| .|..|..:.:..||.|.|::||::|:.|:
Human    82 LAIIRAMTTLGIDYAEPSCADDGRQLNNLADSIEEGTMPPELVEVIRRLWKDGGVQACFERAAEY 146

  Fly   160 PLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGISQITFRVPIPKSMGGGEQQFQMYDVGG 224
            .|.|||.|:|:...||:|.||:||.:|:|.||..||||.:..|.|.        :..|:|:||||
Human   147 QLNDSASYYLNQLERITDPEYLPSEQDVLRSRVKTTGIIETKFSVK--------DLNFRMFDVGG 203

  Fly   225 QRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLASAGLIVFL 289
            ||.:|.|||..|||:..::|..:.|.:|..|.||...||:.|:|.||.::..::|.|:..:::||
Human   204 QRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFL 268

  Fly   290 NKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQEPFKRHSRNQ 354
            ||.|:.|.||:. .|:...||||:.       :|.:.::.   .:||.:.:|:       :.|..
Human   269 NKKDLFEEKIKK-VHLSICFPEYDG-------NNSYDDAG---NYIKSQFLDL-------NMRKD 315

  Fly   355 VDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF 399
            |      :|.|.|.|.||||:.::.||..|..:|:.||:...|||
Human   316 V------KEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	132/366 (36%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	127/344 (37%)
GNAT2	NP_001364224.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		2/9 (22%)
		G-alpha	34..348	CDD:206639	128/345 (37%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		9/12 (75%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		4/6 (67%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750