DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galphaf and GNAT1

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_000163.2	Gene:	GNAT1 / 2779	HGNCID:	4393	Length:	350	Species:	Homo sapiens

Alignment Length:	379	Identity:	133/379 - (35%)
Similarity:	215/379 - (56%)	Gaps:	39/379 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EDQYPVSLDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIY 88
            |:::...|:..:.:|..|..|  |||:||||..||||:||:|||:|:|.:|::.:|..|.|..||
Human     8 EEKHSRELEKKLKEDAEKDAR--TVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIY 70

  Fly    89 QNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE-YMNEEYCDHVTTLWNDVGIRAC 152
            .|..:|||.:|..|..|.|.:|....:..|..::.:..:..| .|.:|..|.:..||.|.||:||
Human    71 GNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQAC 135

  Fly   153 YDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGI--SQITFRVPIPKSMGGGEQ 215
            ::|::|:.|.|||.|:|.:..|:....|:|:.:|:|.||..||||  :|.:|:          :.
Human   136 FERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFK----------DL 190

  Fly   216 QFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFL 280
            .|:|:||||||.:|.|||..|||:..::|:.:.|.:|..|.||...||:.|:|.||.::..:|:.
Human   191 NFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYF 255

  Fly   281 ASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQE 345
            |:..:::||||.|:...||:.. |:...||:|:.       .|.:.::.   .:||.:.:::
Human   256 ATTSIVLFLNKKDVFFEKIKKA-HLSICFPDYDG-------PNTYEDAG---NYIKVQFLEL--- 306

  Fly   346 PFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF 399
                :.|..|      :|.|.|.|.||||:.::.||..|..:|:.||:...|||
Human   307 ----NMRRDV------KEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	129/369 (35%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	122/346 (35%)
GNAT1	NP_000163.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/12 (17%)
		G-alpha	30..344	CDD:206639	123/347 (35%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	31..44		9/12 (75%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	169..177		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	192..201		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	261..268		4/6 (67%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	320..325		3/4 (75%)
		Interaction with RHO. /evidence=ECO:0000250\|UniProtKB:P04695	340..350		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750