Protein Alignment Galphaf and GNAT1

DIOPT Version :10

• Sequence 1: NP_524118.1
• Gene: Galphaf / 39861
• FlyBaseID: FBgn0010223
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_000163.2
• Gene: GNAT1 / 2779
• HGNCID: 4393
• Length: 350
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 133/379 - (35%)
• Similarity: 215/379 - (56%)
• Gaps: 39/379 - (10%)

  Fly    24 EDQYPVSLDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIY 88
            |:::...|:..:.:|..|..|  |||:||||..||||:||:|||:|:|.:|::.:|..|.|..||
Human     8 EEKHSRELEKKLKEDAEKDAR--TVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIY 70

  Fly    89 QNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE-YMNEEYCDHVTTLWNDVGIRAC 152
            .|..:|||.:|..|..|.|.:|....:..|..::.:..:..| .|.:|..|.:..||.|.||:||
Human    71 GNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQAC 135

  Fly   153 YDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGI--SQITFRVPIPKSMGGGEQ 215
            ::|::|:.|.|||.|:|.:..|:....|:|:.:|:|.||..||||  :|.:|:          :.
Human   136 FERASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFK----------DL 190

  Fly   216 QFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFL 280
            .|:|:||||||.:|.|||..|||:..::|:.:.|.:|..|.||...||:.|:|.||.::..:|:.
Human   191 NFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYF 255

  Fly   281 ASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQE 345
            |:..:::||||.|:...||:.. |:...||:|:.       .|.:.::.   .:||.:.:::
Human   256 ATTSIVLFLNKKDVFFEKIKKA-HLSICFPDYDG-------PNTYEDAG---NYIKVQFLEL--- 306

  Fly   346 PFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF 399
                :.|..|      :|.|.|.|.||||:.::.||..|..:|:.||:...|||
Human   307 ----NMRRDV------KEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	129/369 (35%)
GNAT1	NP_000163.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		2/12 (17%)
		G-alpha	30..344	CDD:206639	123/347 (35%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	31..44		9/12 (75%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	169..177		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	192..201		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	261..268		4/6 (67%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	320..325		3/4 (75%)
		Interaction with RHO. /evidence=ECO:0000250|UniProtKB:P04695	340..350		3/9 (33%)