DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and GNAQ

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_002063.2	Gene:	GNAQ / 2776	HGNCID:	4390	Length:	359	Species:	Homo sapiens

Alignment Length:	396	Identity:	136/396 - (34%)
Similarity:	214/396 - (54%)	Gaps:	45/396 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLRCLRQQPAKPAAVMTHKEDQYPVSLDHHVLKDMAKGVRDT--TVKILLLGTAESGKTTIIKQM 67
            ::.|...:.||.|.           .::..:.:.:.:..||.  .:|:|||||.||||:|.||||
Human     6 IMACCLSEEAKEAR-----------RINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQM 59

  Fly    68 RILHINGFTDDERREKIPEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPEYM 132
            ||:|.:|::|:::|.....:||||..::..::..|..|.|.:....::..|..:..:........
Human    60 RIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAF 124

  Fly   133 NEEYCDHVTTLWNDVGIRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGI 197
            ...|.|.:.:||||.||:.||||..|:.|.||.||:|::..|::|..|:|:.:|:|..|..||||
Human   125 ENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGI 189

  Fly   198 SQITFRVPIPKSMGGGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQN 262
            .:..|.:.        ...|:|.||||||.:|.|||..||.:.:::||::.||:||.|.|..::|
Human   190 IEYPFDLQ--------SVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNEN 246

  Fly   263 RLQEALKLFRAVWQNRFLASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGE 327
            |::|:..|||.:....:..::.:|:||||.|::|.||.. .|:|||||||:.    ||:|
Human   247 RMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMY-SHLVDYFPEYDG----PQRD----- 301

  Fly   328 SDWTKMFIKQKLVDITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSEN 392
            :...:.||.:..||:..:              |::..|.|||.||||..||.||..|:..||..|
Human   302 AQAAREFILKMFVDLNPD--------------SDKIIYSHFTCATDTENIRFVFAAVKDTILQLN 352

  Fly   393 VSSMGL 398
            :....|
Human   353 LKEYNL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	131/368 (36%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	128/343 (37%)
GNAQ	NP_002063.2	G-alpha	40..353	CDD:206639	128/344 (37%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750