Protein Alignment Galphaf and GNAL

DIOPT Version :9

• Sequence 1: NP_524118.1
• Gene: Galphaf / 39861
• FlyBaseID: FBgn0010223
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_892023.1
• Gene: GNAL / 2774
• HGNCID: 4388
• Length: 458
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 149/415 - (35%)
• Similarity: 237/415 - (57%)
• Gaps: 54/415 - (13%)

  Fly     8 CLRQQPAKPAAVMTHKE----DQYPVSLDHHVLKD---MAKGV--------RD--TTVKILLLGT 55
            |.|.:..||.......|    ::...:.:...:|:   :::|:        ||  .|.::||||.
Human    63 CARPKADKPKEKRQRTEQLSAEEREAAKEREAVKEARKVSRGIDRMLRDQKRDLQQTHRLLLLGA 127

  Fly    56 AESGKTTIIKQMRILHINGFTDDERREKIPEIYQNIHESILQLVGQMGVL--GIDFGSCTSERSA 118
            .||||:||:|||||||:|||..:|:::||.:|.:|:.::|:.:|..|..:  .:...:..::..:
Human   128 GESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRS 192

  Fly   119 DYILSLPGSAP----EYMNEEYCDHVTTLWNDVGIRACYDRSNEFPLLDSAKYFLDNFVRISDAE 179
            |||.|:   ||    || ::|:.|||..||:|.|::||::||||:.|:|.|:|||:....:|..:
Human   193 DYIKSI---APITDFEY-SQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVD 253

  Fly   180 YIPSTEDILHSRKITTGISQITFRVPIPKSMGGGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLF 244
            |.|:.:|:|..|.:|:||.:..|:|        .:..|.|:|||||||:|.||||.|..:.|:::
Human   254 YTPTDQDLLRCRVLTSGIFETRFQV--------DKVNFHMFDVGGQRDERRKWIQCFNDVTAIIY 310

  Fly   245 LISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLASAGLIVFLNKYDIMERKIRAGK-HIVDY 308
            :.:||.::..:|||.:.|||:|:|.||.::|.||:|.:..:|:||||.|::..|:.||| .|.||
Human   311 VAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDY 375

  Fly   309 FPEYEDFCKRPQQDNCFGES---DWTKMFIKQKLVDITQEPFKRHSRNQVDLGTSERECYYHFTV 370
            ||||.::..........||.   ...|.||:...:.|:           ...|..:..||.|||.
Human   376 FPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRIS-----------TATGDGKHYCYPHFTC 429

  Fly   371 ATDTRCIRDVFCD----VQKMILSE 391
            |.||..||.||.|    :|:|.|.:
Human   430 AVDTENIRRVFNDCRDIIQRMHLKQ 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	144/389 (37%)
		G-alpha	48..392	CDD:206639	139/358 (39%)
GNAL	NP_892023.1	G_alpha	99..455	CDD:214595	143/379 (38%)
		G-alpha	120..452	CDD:206639	138/354 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S897
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325067at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10218
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.760