DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and GNAI3

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_006487.1	Gene:	GNAI3 / 2773	HGNCID:	4387	Length:	354	Species:	Homo sapiens

Alignment Length:	383	Identity:	137/383 - (35%)
Similarity:	214/383 - (55%)	Gaps:	43/383 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EDQYPVS----LDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKI 84
            ||:..|.    :|.::.:|..|..::  ||:||||..||||:||:|||:|:|.:|:::||.::..
Human     8 EDKAAVERSKMIDRNLREDGEKAAKE--VKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYK 70

  Fly    85 PEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE-YMNEEYCDHVTTLWNDVG 148
            ..:|.|..:||:.::..||.|.||||.......|..:..|.|||.| .|..|....:..||.|.|
Human    71 VVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTPELAGVIKRLWRDGG 135

  Fly   149 IRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGI--SQITFRVPIPKSMG 211
            ::||:.||.|:.|.|||.|:|::..|||.:.|||:.:|:|.:|..||||  :..||:
Human   136 VQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFK-------- 192

  Fly   212 GGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQ 276
              :..|:|:||||||.:|.|||..|||:.|::|.::.|::|..|.||...||:.|::|||.::..
Human   193 --DLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICN 255

  Fly   277 NRFLASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVD 341
            |::.....:|:||||.|:.|.||:.....:.| |||..       .|.:.|:   ..:|:.:..|
Human   256 NKWFTETSIILFLNKKDLFEEKIKRSPLTICY-PEYTG-------SNTYEEA---AAYIQCQFED 309

  Fly   342 ITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF 399
            :.:.             ...:|.|.|||.||||:.::.||..|..:|:..|:...||:
Human   310 LNRR-------------KDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	132/373 (35%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	128/346 (37%)
GNAI3	NP_006487.1	G-alpha	34..348	CDD:206639	128/347 (37%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		9/12 (75%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750