Protein Alignment Galphaf and GNAI2

DIOPT Version :9

• Sequence 1: NP_524118.1
• Gene: Galphaf / 39861
• FlyBaseID: FBgn0010223
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_002061.1
• Gene: GNAI2 / 2771
• HGNCID: 4385
• Length: 355
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 132/373 - (35%)
• Similarity: 208/373 - (55%)
• Gaps: 40/373 - (10%)

  Fly    31 LDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIYQNIHESI 95
            :|.::.:|..|..|:  ||:||||..||||:||:|||:|:|.:|::::|.|:....:|.|..:||
Human    19 IDKNLREDGEKAARE--VKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSI 81

  Fly    96 LQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE--YMNEEYCDHVTTLWNDVGIRACYDRSNE 158
            :.:|..||.|.|||...:....|..:.:|..:|.|  .:.::....:..||.|.|::||:.||.|
Human    82 MAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSRE 146

  Fly   159 FPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGI--SQITFRVPIPKSMGGGEQQFQMYD 221
            :.|.|||.|:|::..||:.::|||:.:|:|.:|..||||  :..||:          :..|:|:|
Human   147 YQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFK----------DLHFKMFD 201

  Fly   222 VGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLASAGLI 286
            |||||.:|.|||..|||:.|::|.::.|.:|..|.||...||:.|::|||.::..|::.....:|
Human   202 VGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSII 266

  Fly   287 VFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQEPFKRHS 351
            :||||.|:.|.|| ....:...||||....|          .|....:|:.|..|:.:.
Human   267 LFLNKKDLFEEKI-THSPLTICFPEYTGANK----------YDEAASYIQSKFEDLNKR------ 314

  Fly   352 RNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF 399
                   ...:|.|.|||.||||:.::.||..|..:|:..|:...|||
Human   315 -------KDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	129/369 (35%)
		G-alpha	48..392	CDD:206639	124/347 (36%)
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	124/348 (36%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		9/12 (75%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		3/7 (43%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		5/6 (83%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750