DRSC/TRiP Functional Genomics Resources

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Protein Alignment Galphaf and GNAI1

DIOPT Version :9

Sequence 1:NP_524118.1 Gene:Galphaf / 39861 FlyBaseID:FBgn0010223 Length:399 Species:Drosophila melanogaster
Sequence 2:NP_002060.4 Gene:GNAI1 / 2770 HGNCID:4384 Length:354 Species:Homo sapiens


Alignment Length:383 Identity:136/383 - (35%)
Similarity:214/383 - (55%) Gaps:43/383 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 EDQYPVS----LDHHVLKDMAKGVRDTTVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKI 84
            ||:..|.    :|.::.:|..|..|:  ||:||||..||||:||:|||:|:|..|::::|.::..
Human     8 EDKAAVERSKMIDRNLREDGEKAARE--VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYK 70

  Fly    85 PEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPE-YMNEEYCDHVTTLWNDVG 148
            ..:|.|..:||:.::..||.|.||||.......|..:..|.|:|.| :|..|....:..||.|.|
Human    71 AVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSG 135

  Fly   149 IRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGI--SQITFRVPIPKSMG 211
            ::||::||.|:.|.|||.|:|::..||:...|||:.:|:|.:|..||||  :..||:        
Human   136 VQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFK-------- 192

  Fly   212 GGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQ 276
              :..|:|:||||||.:|.|||..|||:.|::|.::.|::|..|.||...||:.|::|||.::..
Human   193 --DLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICN 255

  Fly   277 NRFLASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVD 341
            |::.....:|:||||.|:.|.||:.....:.| |||..       .|.:.|:   ..:|:.:..|
Human   256 NKWFTDTSIILFLNKKDLFEEKIKKSPLTICY-PEYAG-------SNTYEEA---AAYIQCQFED 309

  Fly   342 ITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGLF 399
            :.:.             ...:|.|.|||.||||:.::.||..|..:|:..|:...|||
Human   310 LNKR-------------KDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GalphafNP_524118.1 G_alpha 30..397 CDD:214595 130/373 (35%)
G-alpha 48..392 CDD:206639 125/346 (36%)
GNAI1NP_002060.4 G-alpha 34..348 CDD:206639 125/347 (36%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 35..48 9/12 (75%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 173..181 3/7 (43%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 196..205 6/8 (75%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 265..272 5/6 (83%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 324..329 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151730
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D754573at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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