Protein Alignment Galphaf and GNA12

DIOPT Version :9

• Sequence 1: NP_524118.1
• Gene: Galphaf / 39861
• FlyBaseID: FBgn0010223
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_031379.2
• Gene: GNA12 / 2768
• HGNCID: 4380
• Length: 381
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 129/360 - (35%)
• Similarity: 186/360 - (51%)
• Gaps: 46/360 - (12%)

  Fly    48 VKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIYQNIHESILQLVGQMGVLGIDFGSC 112
            |||||||..||||:|.:|||||:|...|......|....|:.||.:....||.....|||.:...
Human    58 VKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYS 122

  Fly   113 TSERSADYILSLPGSA-----PEYMNEEYCDHVTTLWNDVGIRACYDRSNEFPLLDSAKYFLDNF 172
            .:|:...::::....|     |... :.|...::.||.|.|||..:.|.:||.|.:|.||||||.
Human   123 ENEKHGMFLMAFENKAGLPVEPATF-QLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNL 186

  Fly   173 VRISDAEYIPSTEDILHSRKITTGISQITFRV-PIPKSMGGGEQQFQMYDVGGQRDQRNKWIQVF 236
            .||....|.||.:|||.:||.|.||.:..|.: .||         |:|.||||||.||.||.|.|
Human   187 DRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIP---------FKMVDVGGQRSQRQKWFQCF 242

  Fly   237 EGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLASAGLIVFLNKYDIMERKIRA 301
            :||.::||::|.||:||.|.||...|||.|::.:|..:..|:...:..:|:||||.|::..|::.
Human   243 DGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKT 307

  Fly   302 GKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQ---EPFKRHSRNQVDLGTSERE 363
             ..|..:||::.            |:        ..:|.|:.:   :.|.|..||:      .:.
Human   308 -VSIKKHFPDFR------------GD--------PHRLEDVQRYLVQCFDRKRRNR------SKP 345

  Fly   364 CYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGL 398
            .::|||.|.||..:|.||..|:..||.||:..:.|
Human   346 LFHHFTTAIDTENVRFVFHAVKDTILQENLKDIML 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	128/357 (36%)
		G-alpha	48..392	CDD:206639	126/352 (36%)
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	128/357 (36%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	59..72		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	200..208		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	223..232		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	292..299		5/6 (83%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	351..356		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750