DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and GNA11

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_002058.2	Gene:	GNA11 / 2767	HGNCID:	4379	Length:	359	Species:	Homo sapiens

Alignment Length:	370	Identity:	132/370 - (35%)
Similarity:	205/370 - (55%)	Gaps:	34/370 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LDHHVLKDMAKGVRDT--TVKILLLGTAESGKTTIIKQMRILHINGFTDDERREKIPEIYQNIHE 93
            ::..:.|.:.:..||.  .:|:|||||.||||:|.||||||:|..|::::::|.....:||||..
Human    21 INAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFT 85

  Fly    94 SILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAPEYMNEEYCDHVTTLWNDVGIRACYDRSNE 158
            ::..::..|..|.|.:....::.:|..|..:..........:|...:.|||.|.||:.||||..|
Human    86 AMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRRE 150

  Fly   159 FPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTGISQITFRVPIPKSMGGGEQQFQMYDVG 223
            :.|.|||||:|.:..||:...|:|:.:|:|..|..||||.:..|.:.        ...|:|.|||
Human   151 YQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLE--------NIIFRMVDVG 207

  Fly   224 GQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPSQNRLQEALKLFRAVWQNRFLASAGLIVF 288
            |||.:|.|||..||.:.:::||::.||:||.|.|..::||::|:..|||.:....:..::.:|:|
Human   208 GQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILF 272

  Fly   289 LNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCFGESDWTKMFIKQKLVDITQEPFKRHSRN 353
            |||.|::|.|| ...|:||||||::.    ||:|     :...:.||.:..||:..:
Human   273 LNKKDLLEDKI-LYSHLVDYFPEFDG----PQRD-----AQAAREFILKMFVDLNPD-------- 319

  Fly   354 QVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILSENVSSMGL 398
                  |::..|.|||.||||..||.||..|:..||..|:....|
Human   320 ------SDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNL 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	131/367 (36%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	127/343 (37%)
GNA11	NP_002058.2	G-alpha	40..353	CDD:206639	127/344 (37%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		3/7 (43%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750