DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphaf and Gna13

DIOPT Version :9

Sequence 1:	NP_524118.1	Gene:	Galphaf / 39861	FlyBaseID:	FBgn0010223	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_034433.3	Gene:	Gna13 / 14674	MGIID:	95768	Length:	377	Species:	Mus musculus

Alignment Length:	398	Identity:	144/398 - (36%)
Similarity:	212/398 - (53%)	Gaps:	52/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PAAVMTHKEDQYPVSLDHHVLKDMAKGV-RDTT-----VKILLLGTAESGKTTIIKQMRILHING 74
            |..|:|:.|.:     .....|::.|.: |:.|     |||||||..||||:|.:|||||:|...
Mouse    16 PGCVLTNGEAE-----QQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQD 75

  Fly    75 FTDDERREKIPEIYQNIHESILQLVGQMGVLGIDFGSCTSERSADYILSLPGSAP---EYMNE-- 134
            |....|.|..|.||.|:.:.:..||.....|.|.:|...::...|.:::....||   :.|.|
Mouse    76 FDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQLHGDKLMAFDTRAPMAAQGMVETR 140

  Fly   135 ---EYCDHVTTLWNDVGIRACYDRSNEFPLLDSAKYFLDNFVRISDAEYIPSTEDILHSRKITTG 196
               :|...:..||.|.||:..|||..||.|.:|.||||||..::...:||||.:|||.:|:.|.|
Mouse   141 VFLQYLPAIRALWEDSGIQNAYDRRREFQLGESVKYFLDNLDKLGVPDYIPSQQDILLARRPTKG 205

  Fly   197 ISQITFRVP-IPKSMGGGEQQFQMYDVGGQRDQRNKWIQVFEGIQAVLFLISCSEFDQNLREDPS 260
            |.:..|.:. :|         |:|.||||||.:|.:|.:.|:.:.::|||:|.|||||.|.||..
Mouse   206 IHEYDFEIKNVP---------FKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRQ 261

  Fly   261 QNRLQEALKLFRAVWQNRFLASAGLIVFLNKYDIMERKIRAGKHIVDYFPEYEDFCKRPQQDNCF 325
            .|||.|:|.:|..:..||..::..:|:||||.|::|.|::. ..|.|||.|:|.      ..:|.
Mouse   262 TNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKVQV-VSIKDYFLEFEG------DPHCL 319

  Fly   326 GESDWTKMFIKQKLVDITQEPFKRHSRNQVDLGTSERECYYHFTVATDTRCIRDVFCDVQKMILS 390
            .:       :::.||    |.|:...|:|     .:|..|:|||.|.:|..||.||.||:..||.
Mouse   320 RD-------VQKFLV----ECFRGKRRDQ-----QQRPLYHHFTTAINTENIRLVFRDVKDTILH 368

  Fly   391 ENVSSMGL 398
            :|:..:.|
Mouse   369 DNLKQLML 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphaf	NP_524118.1	G_alpha	30..397	CDD:214595	139/381 (36%)
Galphaf	NP_524118.1	G-alpha	48..392	CDD:206639	134/352 (38%)
Gna13	NP_034433.3	G_alpha	29..375	CDD:214595	139/377 (37%)
		G-alpha	49..371	CDD:206639	134/353 (38%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	50..63		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	195..203		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	218..227		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	287..294		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	347..352		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750