Protein Alignment CG4098 and TRPM2

DIOPT Version :10

• Sequence 1: NP_660192.1
• Gene: CG4098 / 39854
• FlyBaseID: FBgn0036648
• Length: 307
• Species: Drosophila melanogaster
• Sequence 2: NP_001307279.2
• Gene: TRPM2 / 7226
• HGNCID: 12339
• Length: 1553
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 113/283 - (39%)
• Similarity: 169/283 - (59%)
• Gaps: 20/283 - (7%)

  Fly    33 KPGIFRHLMCRNNMYPRSSVLRYPVSDEQVFWSEPFPDYCPPAYTAPHIGGQVWADPPLPSDTFW 97
            :||...|:..|:.:||...|.|:||.:|:|.|...|..|.||.|||....... .||  ..||..
Human  1283 EPGDSYHVNARHLLYPNCPVTRFPVPNEKVPWETEFLIYDPPFYTAERKDAAA-MDP--MGDTLE 1344

  Fly    98 P----QWNQLDGQVNRESFHGAYNVQNGLPLNPIGRTGLTGRGSLGRWGPNHAADPIVTRWKRDD 158
            |    |:|.:||..:|.||||.|.||.||||||:|||||.|||||..:||||...|:||||:|::
Human  1345 PLSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNE 1409

  Fly   159 QGAIVANPTTGKNIIQMVAIQRSDNKLWAIPGGMVDPGENVSVTLKREFTEEALNFTDKANMVER 223
            .|||.....  |.:::::.::...::.||:|||..:|||.:...|||...:|  ::....|:::
Human  1410 DGAICRKSI--KKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQE--HWPSFENLLK- 1469

  Fly   224 FFQAGGVQVYQGYVDDFRNTDNAWMETTALNFH--DEDGSQVGQL--ELMAGDDASNVRWTDVDS 284
                .|::||:||:||.|||||||:||.|::.|  |::..::.:|  .|.|.|..:::||..||.
Human  1470 ----CGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDR 1530

  Fly   285 NLKLHANHADIVREVVIRRNAHW 307
            .:.|:|||..::::......||:
Human  1531 RIPLYANHKTLLQKAAAEFGAHY 1553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4098	NP_660192.1	NUDIX_ADPRase_Nudt9	125..303	CDD:467538	70/181 (39%)
TRPM2	NP_001307279.2	LSDAT_euk	141..364	CDD:476852
		Ion_trans	803..>979	CDD:459842
		NUDIX_ADPRase_Nudt9	1376..1549	CDD:467538	70/181 (39%)