DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4098 and Trpm2

DIOPT Version :9

Sequence 1:	NP_660192.1	Gene:	CG4098 / 39854	FlyBaseID:	FBgn0036648	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_612174.2	Gene:	Trpm2 / 28240	MGIID:	1351901	Length:	1506	Species:	Mus musculus

Alignment Length:	310	Identity:	112/310 - (36%)
Similarity:	167/310 - (53%)	Gaps:	40/310 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ENPLTSAQMMSSLVKPGIFRHLMCRNNMYPRSSVLRYPVSDEQVFWSEPFPDYCPPAYTAPHIGG 83
            :.|.....:...:.:||...|:..|:.:||.:.::|:||.:|:|.|:..|..|.||.|||..  .
Mouse  1216 DEPDAELSIRRKVEEPGDGYHVSARHLLYPNARIMRFPVPNEKVPWAAEFLIYDPPFYTAEK--D 1278

  Fly    84 QVWADPPLPSDTFWP----QWNQLDGQVNRESFHGAYNVQNGLPLNPIGRTGLTGRGSLGRWGPN 144
            ....||  ..||..|    .:|.:||..:|.||||.|.|:.|.||||:|||||.|||||..:|||
Mouse  1279 VALTDP--VGDTAEPLSKISYNVVDGPTDRRSFHGVYVVEYGFPLNPMGRTGLRGRGSLSWFGPN 1341

  Fly   145 HAADPIVTRWKRDDQGAIVANPTTGKNIIQMVAIQRSDNKLWAIPGGMVDPGENVSVTLKREFTE 209
            |...|:||||||:..|||.....  :.:::::.::...::.||:|||..:|||.:...|||...:
Mouse  1342 HTLQPVVTRWKRNQGGAICRKSV--RKMLEVLVMKLPRSEHWALPGGSREPGEMLPRKLKRVLRQ 1404

  Fly   210 EALNFTDKANMVERFFQA------GGVQVYQGYVDDFRNTDNAWMETTALNFH--DEDGSQVGQL 266
            |             |:.|      .|.:||:|||||.|||||||:||.|::.|  |::..::.:|
Mouse  1405 E-------------FWVAFETLLMQGTEVYKGYVDDPRNTDNAWIETVAVSIHFQDQNDMELKRL 1456

  Fly   267 E---------LMAGDDASNVRWTDVDSNLKLHANHADIVREVVIRRNAHW 307
            |         .:..|...:..|..||..:.|:|||..|:::|.....||:
Mouse  1457 EENLHTHDPKELTRDLKLSTEWQVVDRRIPLYANHKTILQKVASLFGAHF 1506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4098	NP_660192.1	ADPRase_NUDT9	125..303	CDD:239642	72/194 (37%)
Trpm2	NP_612174.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		LSDAT_euk	140..363	CDD:423023
		trp	<716..1071	CDD:273311
		Ion_trans	800..>976	CDD:395416
		Nudix_Hydrolase	1322..1502	CDD:412381	72/194 (37%)
		Nudix box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00794	1386..1407		8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4195
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810