Protein Alignment spd-2 and CEP192

DIOPT Version :9

• Sequence 1: NP_648906.1
• Gene: spd-2 / 39850
• FlyBaseID: FBgn0027500
• Length: 1146
• Species: Drosophila melanogaster
• Sequence 2: XP_005258164.1
• Gene: CEP192 / 55125
• HGNCID: 25515
• Length: 2538
• Species: Homo sapiens
• Alignment Length: 1487
• Identity: 303/1487 - (20%)
• Similarity: 493/1487 - (33%)
• Gaps: 498/1487 - (33%)

  Fly     7 SQGNGSFMDQNSL-GILNMDNLKVFGDLSSFSKSGRRSGTGRDSPAV--------HERLREERLR 62
            |:...||...||. .:.|.:|.....|:.:.|...:....|.|..|.        :..:|..|:.
Human   852 SENQESFRTINSSNSVTNRENNSAVVDVKTCSIDNKLQDVGNDEKATSISTPSDSYSSVRNPRIT 916

  Fly    63 A---LETLEKPRPSRSSQAKSTAL------QMRLSTNISELVTDDTIDLNSSS------------ 106
            :   |:..|:.|.:|.:|.::..:      :..::.....:|:....||.::|
Human   917 SLCLLKDCEEIRDNRENQRQNECVSEISNSEKHVTFENHRIVSPKNSDLKNTSPEHGGRGSEDEQ 981

  Fly   107 -SFALVTPATKGTNISFEPAEITGRST----LCQAGKQRRREKPS---------LSVAEILKSSF 157
             ||   .|:|...:.| .|:||:|.|:    |...|...::::|.         .|.|.:.:.::
Human   982 ESF---RPSTSPLSHS-SPSEISGTSSSGCALESFGSAAQQQQPPCEQELSPLVCSPAGVSRLTY 1042

  Fly   158 VEKAR----------LLERKLQDASQAEASYHLSRGSSSSLSDSFNCSRSLPRTADMSELSLNGG 212
            |.:..          .||.:..|.: :|.|..:.:||.::|.:     |::.:..:.......|.
Human  1043 VSEPESSYPTTATDDALEDRKSDIT-SELSTTIIQGSPAALEE-----RAMEKLREKVPFQNRGK 1101

  Fly   213 GGFS------------FGSASLAAE----------GQDESFAPAELMQSKLVLGEISWA---QEF 252
            |..|            ..:.||:::          .:|.|.....|:::    .|:.|.   :|.
Human  1102 GTLSSIIQNNSDTRKATETTSLSSKPEYVKPDFRWSKDPSSKSGNLLET----SEVGWTSNPEEL 1162

  Fly   253 TAMPTATLSTQALKKIAAPTSEIETSVSNSVLAGDP-----------------DFSLGNYFQTRS 300
            ..:..|.|....|      :.::.::.|:.|...:|                 :||.....||.|
Human  1163 DPIRLALLGKSGL------SCQVGSATSHPVSCQEPIDEDQRISPKDKSTAGREFSGQVSHQTTS 1221

  Fly   301 ENIWNIVSNSSPNRS---RTNQP------LLEPESNV---------TLDSVGEKT-PQ--PDNKT 344
            ||....:.:|:.:.|   ..|.|      |.:|..:.         ||.|.|..| ||  ..|.|
Human  1222 ENQCTPIPSSTVHSSVADMQNMPAAVHALLTQPSLSAAPFAQRYLGTLPSTGSTTLPQCHAGNAT 1286

  Fly   345 Y--------------------TKTDAITGSNLGRNLM----------RKMQQDRIETALK----- 374
            .                    .......|||:|...|          ..:.|:.:.|...
Human  1287 VCGFSGGLPYPAVAGEPVQNSVAVGICLGSNIGSGWMGTSSLCNPYSNTLNQNLLSTTKPFPVPS 1351

  Fly   375 -------------SRNGLAA----KETKRPP------SSSEILS-LSAIDKALR------DIDLN 409
                         ..:||.:    :|.|.|.      :|..:|| |:..|:.|:      .|.:|
Human  1352 VGTNCGIEPWDSGVTSGLGSVRVPEELKLPHACCVGIASQTLLSVLNPTDRWLQVSIGVLSISVN 1416

  Fly   410 S---DTSTVEVVNHLWEHGRGNNYDDGENKENQSSNSHAER--------TSCGSNKLTDTMSFTD 463
            .   |.||...:..               |.......||..        :|.|..:.|.:::
Human  1417 GEKVDLSTYRCLVF---------------KNKAIIRPHATEEIKVLFIPSSPGVFRCTFSVA--- 1463

  Fly   464 SVLNSTDFRHLQQS---ISRKPLSPLADHPQITISRADTDPVETEAEADID-------EWPSTPV 518
            |...|||...:.|:   .|...|:.:|:.|.|        .||||.:..:|       .|.:.|:
Human  1464 SWPCSTDAETIVQAEALASTVTLTAIAESPVI--------EVETEKKDVLDFGDLTYGGWKALPL 1520

  Fly   519 KEPSR--------------------------RVRR-TKISP------RAASPSSSDGVRPLTCTE 550
            |..:|                          .||. .:::|      |.|.||..:.:.|  .:.
Human  1521 KLINRTHATVPIRLIINANAVAWRCFTFSKESVRAPVEVAPCADVVTRLAGPSVVNHMMP--ASY 1583

  Fly   551 DENDEEDEDKTPVNKKRVSIATMGLIPRKASSLSSTRLDGCDVAVASSTERDFGI-SPNLAKNLS 614
            |..|.|          .:.|..:...|:|..|.|    |..|.|...|.:.|..: |||....|.
Human  1584 DGQDPE----------FLMIWVLFHSPKKQISSS----DILDSAEEFSAKVDIEVDSPNPTPVLR 1634

  Fly   615 PLS-----------SPRSCLSSPLLDSTTSSDRRQL-MSGAAR--------------------KA 647
            .:|           :||...:...|....||.::.| :..|..                    |.
Human  1635 SVSLRARAGIARIHAPRDLQTMHFLAKVASSRKQHLPLKNAGNIEVYLDIKVPEQGSHFSVDPKN 1699

  Fly   648 NSSPAGSEASSTSGFTASG-----------------------RRGLGTSSVAVPRSISRCSN-SS 688
            .....|.|......||...                       .:|...||.:.|.|...|.: .|
Human  1700 LLLKPGEEHEVIVSFTPKDPEACEERILKIFVQPFGPQYEVVLKGEVISSGSKPLSPGPCLDIPS 1764

  Fly   689 EFSHRDGKLLPLKVTHTTLCWGSTKL-RTDVRKSMQVKNTADKRLVIRLGIQGPG---FQLVGTD 749
            ..|::.           .|.||...| ||.::|.....|:|.....:||.|:|..   |||..|.
Human  1765 ILSNKQ-----------FLAWGGVPLGRTQLQKLALRNNSASTTQHLRLLIRGQDQDCFQLQNTF 1818

  Fly   750 SS--------TITLQAMECRSVVINFCPTVCGAAIGALSFYAPPGAHNSNQPGLE--IPLYGYGG 804
            .|        .|.:...|...:.:.|.||.....:..|..   ....|.:|||::  |||.||||
Human  1819 GSEQRLTSNCEIRIHPKEDIFISVLFAPTRLSCMLARLEI---KQLGNRSQPGIKFTIPLSGYGG 1880

  Fly   805 SAS--------------ITINGLLKGPVGASFLTIGDVCELSAGPLSANLKFHNKGPLTAF---V 852
            :::              :|:|||:.|.......::                 .|.|...||   |
Human  1881 TSNLILEGVKKLSDSYMVTVNGLVPGKESKIVFSV-----------------RNTGSRAAFVKAV 1928

  Fly   853 GISVDS--TVLMKLRLSEAFEVRPSRLILPPNSERCVQILFRPNREDLKNILKKTAQVLTLANMR 915
            |.. ||  .||:..::...|   |.:.:|...::..|.:::.|:...:.|   |||  ..|:.:.
Human  1929 GFK-DSQKKVLLDPKVLRIF---PDKFVLKERTQENVTLIYNPSDRGINN---KTA--TELSTVY 1984

  Fly   916 IFCGDEPNRQRMRSLVQRMSSRQREKLTSP-MLDSIWGE------------FPDEQPVRNIGQLN 967
            :|.|||.:||:.|          |..|..| |:..|..|            |.||..|..:..|.
Human  1985 LFGGDEISRQQYR----------RALLHKPEMIKQILPEHSVLQNINFVEAFQDELLVTEVYDLP 2039

  Fly   968 EPPEFI-LDLVTVVRIIDVALTLNRDFDESSESSLMFLPEADETVLFRTICVANS---------- 1021
            :.|..: |...::.:||...:...||...|.|    ||..:.:..|..|..:..|
Human  2040 QRPNDVQLFYGSMCKIILSVIGEFRDCISSRE----FLQPSSKASLESTSDLGASGKHGGNVSLD 2100

  Fly  1022 --PT--PTQSHLLE-----PVDELLEADTTTLTPVEQNWCVQPGLLEFGVGCSPLATLSVTNSFC 1077
              |.  |..|.||.     |:|:|..         |:.|.|.|..|.. |..|| ..::.|..|
Human  2101 VLPVKGPQGSPLLSRAARPPLDQLAS---------EEPWTVLPEHLIL-VAPSP-CDMAKTGRF- 2153

  Fly  1078 SRQLIEVTCNVPDLVRIS---PSECY-VSPDGG--HAEIDVRLLRSPRQDLLEREPL 1128
                 ::..|...|:|..   |:.|. |:|..|  ..|..:::|.||...|..::.:
Human  2154 -----QIVNNSVRLLRFELCWPAHCLTVTPQHGCVAPESKLQILVSPNSSLSTKQSM 2205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spd-2	NP_648906.1	None
CEP192	XP_005258164.1	ASH	1660..1724	CDD:301105	9/63 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto90028
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7128
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030