Protein Alignment LIMK2 and LIMK1

DIOPT Version :10

• Sequence 1: NP_001026971.1
• Gene: LIMK2 / 3985
• HGNCID: 6614
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Alignment Length: 748
• Identity: 289/748 - (38%)
• Similarity: 410/748 - (54%)
• Gaps: 144/748 - (19%)

Human    15 DLFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMS 79
            |.||||.|:..|.|||:|::|.|||.:||:|:||:.|..|..::|||.|||||.|:|||||.|.:
  Fly    59 DCFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCMAVITGPVMVAGEHKFHPECFCCTA 123

Human    80 CKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA-TTEGRRG 143
            |...|.:|::||||:.:.||||:|:.:....|...:....:..:.: :|:.|:.:|. .|.|.|.
  Fly   124 CGSFIGEGESYALVERSKLYCGQCYGKRSCQPADAKARITTAGKPM-HSIRLVEIPKDATPGLRV 187

Human   144 FSVSVESACSNYATTVQVKEV-------------------NRMHISPNNRNAIHPGDRILEINGT 189
            ..|:::..|    .||::.::                   .|:.::..|   :|.||||||:|||
  Fly   188 DGVALDDGC----PTVRITDLFCNFFLWLTSMAEQCCGAPYRIDVNLTN---LHIGDRILEVNGT 245

Human   190 PVRTLRVEEVEDAISQTSQTLQLLIEHDPV------SQRLDQLRLEAR--LAPHMQNAGHPHALS 246
            ||....||:::..|....:.|||.:|||||      ||...|..:.|.  :.|...:|      |
  Fly   246 PVSDSSVEQIDKLIRSNEKMLQLTVEHDPVQVCRSCSQADIQRAMSASTLILPLSTSA------S 304

Human   247 TLDT-KENL------EGTLRRRSLRRSNSISKSPGPSS---------PKE--------------- 280
            :::. :|.|      :|| :.|.||::.:.|.:..|::         .||
  Fly   305 SVEVGRERLYKTPGEQGT-KARKLRQATNASTTIPPAAGATAMTQLKEKERCSSLSKLLDEQHQA 368

Human   281 ------PLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK 339
                  |.|:  |:||::|.|.... .|:|||..||:.||.||:||||:..||||:.:|:|||:|
  Fly   369 QQHSAHPQLY--DLSRTQSCRVVQK-PQRIFRATDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLK 430

Human   340 ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP--- 401
            ||.|.|||.|:.|:.||.|:|.|||.:||||||||||||||:::|||:.||.||:.:.  ||
  Fly   431 ELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAGGCLKELIH--DPAQV 493

Human   402 FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER------- 459
            .||.|:||.|:.||.||:|||||.||||||||.|||::.|::|:||||||:|.:...|
  Fly   494 LPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSGNMT 558

Human   460 ---------KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVL 515
                     ..|||..:.|.:|: :...|::|||||||||||||||:.|..|||.||:|||||:|
  Fly   559 PGGYGSGANSDAPMSPSGTLRRS-KSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIML 622

Human   516 CEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGEGP 580
            |||||:|.||||.:||..||.||.:.|.|||. ..||..|..:|.:||.|.|:.|.
  Fly   623 CEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQCPEPFVKVAFVCCDLNPDMRP--------- 677

Human   581 GC-----------ADDEGPVRRQGKVTIKYDPKELRKHL-NLEEWILEQLTRLYDCQEEEISELE 633
             |           |||....|        ..|:.|...: ..:||.......|....:..::.|
  Fly   678 -CFETLHVWLQRLADDLAADR--------VPPERLLHEIETFQEWYASSEDALSPTSQRSLNNL- 732

Human   634 IDVDELLD--MESDDAWASRVKELLVDCYKPTE 664
               |||:.  ::|:.:...:.||.:|  .||.:
  Fly   733 ---DELVKSAVDSEISPVEKEKENMV--IKPQD 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK2	NP_001026971.1	LIM	<15..44	CDD:413332	16/28 (57%)
		LIM2_LIMK2	46..104	CDD:188849	30/57 (53%)
		PDZ_LIMK-like	126..218	CDD:467236	32/111 (29%)
		Protein Kinases, catalytic domain	316..570	CDD:473864	150/272 (55%)
		PP1_inhibitor	564..686	CDD:461630	23/115 (20%)
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	16/28 (57%)
		LIM2_LIMK	95..148	CDD:188751	28/52 (54%)
		PDZ_LIMK-like	169..274	CDD:467236	32/112 (29%)
		STKc_LIMK	407..693	CDD:271056	154/299 (52%)