Protein Alignment LIMK2 and Limk2

DIOPT Version :10

• Sequence 1: NP_001026971.1
• Gene: LIMK2 / 3985
• HGNCID: 6614
• Length: 686
• Species: Homo sapiens
• Sequence 2: NP_077049.2
• Gene: Limk2 / 29524
• RGDID: 62056
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 576
• Identity: 532/576 - (92%)
• Similarity: 548/576 - (95%)
• Gaps: 7/576 - (1%)

Human     2 GSY--LSVPAYFTSRD-----LFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMT 59
            |:|  ||...|.|:.:     .|||||||:|||||||||||||||.||||.||||||||||||||
  Rat    16 GNYVPLSQRLYRTANEAWHSSCFRCSECQESLTNWYYEKDGKLYCHKDYWAKFGEFCHGCSLLMT 80

Human    60 GPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQ 124
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
  Rat    81 GPAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQDQ 145

Human   125 LPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGT 189
            |||||||||||||||.|||||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   146 LPYSVTLISMPATTECRRGFSVSVESASSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGT 210

Human   190 PVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENL 254
            ||||||||||||||:|||||||||||||||.||||||||:.||:||||::||...|||||.|||.
  Rat   211 PVRTLRVEEVEDAINQTSQTLQLLIEHDPVPQRLDQLRLDTRLSPHMQSSGHTLMLSTLDAKENQ 275

Human   255 EGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKG 319
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat   276 EGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKG 340

Human   320 FFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT 384
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   341 FFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT 405

Human   385 EYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADF 449
            |||||||||||||::||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   406 EYIEGGTLKDFLRNVDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADF 470

Human   450 GLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIV 514
            ||||||||||||.|:|||.||||||||:||||||||||||||||||||||||||||||:||||||
  Rat   471 GLSRLIVEERKRPPVEKAATKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIV 535

Human   515 LCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESR 570
            |||||||||||||||||||||||||||||||||||||||||||||||||:||||||
  Rat   536 LCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESR 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK2	NP_001026971.1	LIM	<15..44	CDD:413332	24/33 (73%)
		LIM2_LIMK2	46..104	CDD:188849	56/57 (98%)
		PDZ_LIMK-like	126..218	CDD:467236	88/91 (97%)
		Protein Kinases, catalytic domain	316..570	CDD:473864	245/253 (97%)
		PP1_inhibitor	564..686	CDD:461630	6/7 (86%)
Limk2	NP_077049.2	LIM	12..65	CDD:413332	30/48 (63%)
		LIM2_LIMK2	67..125	CDD:188849	56/57 (98%)
		PDZ_LIMK-like	147..239	CDD:467236	88/91 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..304		39/46 (85%)
		STKc_LIMK2	337..608	CDD:271124	247/255 (97%)