DRSC/TRiP Functional Genomics Resources

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Protein Alignment LIMK2 and lrk-1

DIOPT Version :10

Sequence 1:NP_001026971.1 Gene:LIMK2 / 3985 HGNCID:6614 Length:686 Species:Homo sapiens
Sequence 2:NP_492839.4 Gene:lrk-1 / 172995 WormBaseID:WBGene00003068 Length:2393 Species:Caenorhabditis elegans


Alignment Length:411 Identity:98/411 - (23%)
Similarity:152/411 - (36%) Gaps:118/411 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   307 PCDLIHGEVLGKGFFGQAIKVT-HKATGKV--MVMKELIRCD----------------------- 345
            |..|....:||:|.||...:.| .:..|::  :..|.|...|                       
 Worm  1691 PDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRD 1755

Human   346 --EETQKTFLT---EVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQ 405
              |...:.:.|   |:.::..:.||||:..:||.  ...|:|:.|....|.|...|.|      .
 Worm  1756 SMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVC--TFPLSLVVELAPLGALNQLLGS------H 1812

Human   406 QKV----------RFAKGIASGMAYLHSMCIIHRDLNSHNCL---------IKLDKTVVVADFGL 451
            :|.          ..|..:|..:.||||..||:|||.|.|.|         .:.|..:.:.|:|:
 Worm  1813 RKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGI 1877

Human   452 SRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEML--NG-KSYDETVDIFSFGI 513
            ||.::      |...|             |.:.  |...:||||::  || :.|.:.||.||||:
 Worm  1878 SRSVL------PSGGA-------------KGFG--GTEGFMAPEIVRFNGEEEYTQKVDCFSFGM 1921

Human   514 VLCEIIGQVY---ADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGA 575
            .|.|::...:   ::.....|.||....|.|..|..:||    ....|...|....||||  |.:
 Worm  1922 FLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPT----PMLDLLVHCWSAHPESR--PSS 1980

Human   576 AGEGPGCADDEGPVRRQGKVTIKYDPKELRKHLNLEEWILEQLTRLYDCQEEEISELEIDVDELL 640
            :.....||..|        .|...|..||.:.|...:.:...:|                 ||:.
 Worm  1981 SQLVGFCAAPE--------FTHLLDVCELGEALPPTQLMAVGIT-----------------DEID 2020

Human   641 DMESDDA--WASRVKELLVDC 659
            |.:..:|  |.|..:.:::.|
 Worm  2021 DPDDFEAQLWLSGREMVVMGC 2041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LIMK2NP_001026971.1 LIM <15..44 CDD:413332
LIM2_LIMK2 46..104 CDD:188849
PDZ_LIMK-like 126..218 CDD:467236
Protein Kinases, catalytic domain 316..570 CDD:473864 77/309 (25%)
PP1_inhibitor 564..686 CDD:461630 21/98 (21%)
lrk-1NP_492839.4 ANKYR 13..337 CDD:440430
ANK repeat 56..88 CDD:293786
ANK repeat 90..121 CDD:293786
ANK repeat 197..228 CDD:293786
ANK repeat 230..262 CDD:293786
ANK repeat 361..390 CDD:293786
Ank_2 366..472 CDD:463710
ANK repeat 398..432 CDD:293786
LRR <529..>778 CDD:443914
leucine-rich repeat 534..555 CDD:275380
leucine-rich repeat 556..580 CDD:275380
leucine-rich repeat 581..604 CDD:275380
leucine-rich repeat 605..627 CDD:275380
leucine-rich repeat 628..654 CDD:275380
leucine-rich repeat 655..684 CDD:275380
leucine-rich repeat 687..718 CDD:275380
leucine-rich repeat 719..742 CDD:275380
leucine-rich repeat 743..765 CDD:275380
leucine-rich repeat 803..856 CDD:275380
LRR <857..>953 CDD:443914
leucine-rich repeat 857..883 CDD:275380
leucine-rich repeat 884..906 CDD:275380
leucine-rich repeat 907..931 CDD:275380
P-loop containing Nucleoside Triphosphate Hydrolases 977..1160 CDD:476819
COR <1239..>1336 CDD:406489
Protein Kinases, catalytic domain 1699..1990 CDD:473864 82/325 (25%)
Blue background indicates that the domain is not in the aligned region.

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