DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx8 and VAM7

DIOPT Version :9

Sequence 1:	NP_524113.1	Gene:	Syx8 / 39847	FlyBaseID:	FBgn0036643	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_011303.1	Gene:	VAM7 / 852660	SGDID:	S000003180	Length:	316	Species:	Saccharomyces cerevisiae

Alignment Length:	242	Identity:	50/242 - (20%)
Similarity:	97/242 - (40%)	Gaps:	66/242 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WDIEYE----------GCERLRHQLLVYLNQRQQLNPRTSQ----FVQLTSSIQTGIEQLAKDMK 59
            |...|:          |.||..::|   .|.|.....|.::    |:||:   :..:.| .|..:
Yeast    75 WQRRYDDPEMIDERRIGLERFLNEL---YNDRFDSRWRDTKIAQDFLQLS---KPNVSQ-EKSQQ 132

  Fly    60 HLKVVLDNAITWETSPEEELQQRRIDWD-------------RLTSQLREIREKFANS-SRSNVPA 110
            ||:..  :.:.|    :|.::..::|.|             |..::|.::||:.... .:.::|:
Yeast   133 HLETA--DEVGW----DEMIRDIKLDLDKESDGTPSVRGALRARTKLHKLRERLEQDVQKKSLPS 191

  Fly   111 AS------------------GSAWQDQDLGP--GHSNSSRNTALDVEA-----LKQKKTEMLAQQ 150
            ..                  |:|...||.|.  |.:.|..::..:|:.     |:|.:.:|:..|
Yeast   192 TEVTRRAALLRSLLKECDDIGTANIAQDRGRLLGVATSDNSSTTEVQGRTNNDLQQGQMQMVRDQ 256

  Fly   151 NEGLEVLSATLSRQRQLATQLGNEVEDQNNILDNLANAMDRVETGVQ 197
            .:.|..|...:..||.||.::..|::.||.:|..|.:.:|.....:|
Yeast   257 EQELVALHRIIQAQRGLALEMNEELQTQNELLTALEDDVDNTGRRLQ 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx8	NP_524113.1	SNARE_Syntaxin8	147..205	CDD:277205	14/51 (27%)
VAM7	NP_011303.1	PX_SNARE	13..120	CDD:132807	10/47 (21%)
VAM7	NP_011303.1	SNARE_VAM7	253..311	CDD:277211	14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003175
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103098
Panther	1	1.100	-	-	O	PTHR19957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.860