Protein Alignment Syx8 and STX6

DIOPT Version :10

• Sequence 1: NP_524113.1
• Gene: Syx8 / 39847
• FlyBaseID: FBgn0036643
• Length: 232
• Species: Drosophila melanogaster
• Sequence 2: NP_005810.1
• Gene: STX6 / 10228
• HGNCID: 11441
• Length: 255
• Species: Homo sapiens
• Alignment Length: 246
• Identity: 48/246 - (19%)
• Similarity: 107/246 - (43%)
• Gaps: 52/246 - (21%)

  Fly    27 LNQRQQLNPRTSQFVQ------------LTSSIQTGIEQLAKDMKHLKVVLDNAIT-WETSPEE- 77
            :|..|.|..|.::.:|            .|:.::..:..:..|::.    ||..|: .|.:|.:
Human    18 VNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLED----LDETISIVEANPRKF 78

  Fly    78 -----ELQQRRIDWDRLTSQLREIREKFANSS------RSNVPAASGSAWQDQDLGPGHSNSSRN 131
                 ||..|:.........:|:::::.:.||      |.|..|..|.:        |..|.|..
Human    79 NLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDS--------GSQNWSTG 135

  Fly   132 TA-----LD----------VEALKQKKTEMLAQQNEGLEVLSATLSRQRQLATQLGNEVEDQNNI 181
            |.     ||          :|..:.::..::.||:|.||::|.::...:.::.::|.|:|:|..:
Human   136 TTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVM 200

  Fly   182 LDNLANAMDRVETGVQRETQSIGQVNRRDSTWGYWLVIIALFVAIIVVVFV 232
            |::.::.::..::.:....:.:.:|:...|....|..|..||..::||:.:
Human   201 LEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLIL 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx8	NP_524113.1	SNARE_Syntaxin8	147..205	CDD:277205	11/57 (19%)
STX6	NP_005810.1	Required for interaction with VPS51. /evidence=ECO:0000250|UniProtKB:Q63635	2..168		29/161 (18%)
		SNARE_NTD_STX6	5..107	CDD:410573	16/92 (17%)
		SNARE_Syntaxin6	166..231	CDD:277204	12/64 (19%)