DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn12 and PSMD8

DIOPT Version :9

Sequence 1:	NP_648904.1	Gene:	Rpn12 / 39845	FlyBaseID:	FBgn0028693	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_002803.2	Gene:	PSMD8 / 5714	HGNCID:	9566	Length:	350	Species:	Homo sapiens

Alignment Length:	259	Identity:	130/259 - (50%)
Similarity:	186/259 - (71%)	Gaps:	3/259 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYKELTAEWSKRPPNTVKCGQLLDQLKVALVKMAFLPTDGNDAQSSKKQLILARSVLEVAVEHSV 71
            :|::|..||:::.||..|||:.|.:||:.|:::.||||.|  .:.:|:||||||.:||:..:.|:
Human    94 MYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTG--TKLTKQQLILARDILEIGAQWSI 156

  Fly    72 LSKDLLAFERYMAQLKCYYYDYAKIIGESESKYKLLGLNLLYLLSGNRVSDFHTELELLSVDVIQ 136
            |.||:.:||||||||||||:||.:.:.||...::|||||||:|||.|||::||||||.|....||
Human   157 LRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQ 221

  Fly   137 HNQFIRPILALEQYIMEGRYNKIFQAKSTVPVEVYSYFMDLLLETVRDEIGACIEKSYDKISAKD 201
            .|.:|:..::||||:|||.|||:|.||..:|.|.|::|:|:||:|:||||..||||:|:||...:
Human   222 TNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTE 286

  Fly   202 AAKRLNLRVPDEIKAFGAKRQWKLEASGDYSFTDRSVKPKE-LLPSEELAEQVLSYARDLEMIV 264
            |.:.|....|.::..:..||.|.|..:..|||..:..||:: .:||.|||:||:.|||.|||||
Human   287 ATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn12	NP_648904.1	CSN8_PSD8_EIF3K	119..230	CDD:287089	52/110 (47%)
PSMD8	NP_002803.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
PSMD8	NP_002803.2	CSN8_PSD8_EIF3K	201..315	CDD:370807	54/113 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144952
Domainoid	1	1.000	142	1.000	Domainoid score	I4695
eggNOG	1	0.900	-	-		E1_KOG3151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37686
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3080
Isobase	1	0.950	-	0	Normalized mean entropy	S2152
OMA	1	1.010	-	-		QHG53806
OrthoDB	1	1.010	-	-		D1183195at2759
OrthoFinder	1	1.000	-	-		FOG0003512
OrthoInspector	1	1.000	-	-		otm40647
orthoMCL	1	0.900	-	-		OOG6_102164
Panther	1	1.100	-	-	LDO	PTHR12387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1201
SonicParanoid	1	1.000	-	-		X2884
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750