DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn12 and psmd8

DIOPT Version :9

Sequence 1:	NP_648904.1	Gene:	Rpn12 / 39845	FlyBaseID:	FBgn0028693	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_001002131.1	Gene:	psmd8 / 415221	ZFINID:	ZDB-GENE-040625-136	Length:	267	Species:	Danio rerio

Alignment Length:	269	Identity:	140/269 - (52%)
Similarity:	191/269 - (71%)	Gaps:	7/269 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANV----ESLYKELTAEWSKRPPNTVKCGQLLDQLKVALVKMAFLPTDGNDAQSSKKQLILARS 61
            ||:|    ..||:.|.|||:|:.||..|||:||.:||::|:::.||||.|  .:.:|:||||||.
Zfish     1 MASVLKETAGLYETLKAEWNKKNPNLNKCGELLSKLKISLLELNFLPTTG--TKLTKQQLILARD 63

  Fly    62 VLEVAVEHSVLSKDLLAFERYMAQLKCYYYDYAKIIGESESKYKLLGLNLLYLLSGNRVSDFHTE 126
            |||:....|:|.||:.:||||||||||||:||...:.||..:::|||||||:|||.||||:||||
Zfish    64 VLEIGALWSILKKDIPSFERYMAQLKCYYFDYKDELPESAYRHQLLGLNLLFLLSQNRVSEFHTE 128

  Fly   127 LELLSVDVIQHNQFIRPILALEQYIMEGRYNKIFQAKSTVPVEVYSYFMDLLLETVRDEIGACIE 191
            ||.||...||.|.:||..::||||:|||.|||:|.||..:|.|.|::|:|.||:|:||||..|||
Zfish   129 LERLSAKDIQTNVYIRHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDTLLDTIRDEIAGCIE 193

  Fly   192 KSYDKISAKDAAKRLNLRVPDEIKAFGAKRQWKLEASGDYSFTDRSVKPKEL-LPSEELAEQVLS 255
            |:|::|...:|.:.|....|.::..:..||.|.....|.|||:.:..|.:|: :||.|||:||:.
Zfish   194 KAYEQIQFNEATRVLFFSSPKKMTDYAKKRNWTQSPDGYYSFSTQHQKTEEVTIPSTELAKQVIE 258

  Fly   256 YARDLEMIV 264
            |||.|||||
Zfish   259 YARQLEMIV 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn12	NP_648904.1	CSN8_PSD8_EIF3K	119..230	CDD:287089	53/110 (48%)
psmd8	NP_001002131.1	CSN8_PSD8_EIF3K	118..232	CDD:287089	55/113 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578199
Domainoid	1	1.000	142	1.000	Domainoid score	I4638
eggNOG	1	0.900	-	-		E1_KOG3151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37686
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2978
OMA	1	1.010	-	-		QHG53806
OrthoDB	1	1.010	-	-		D1183195at2759
OrthoFinder	1	1.000	-	-		FOG0003512
OrthoInspector	1	1.000	-	-		otm25222
orthoMCL	1	0.900	-	-		OOG6_102164
Panther	1	1.100	-	-	LDO	PTHR12387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1201
SonicParanoid	1	1.000	-	-		X2884
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800