DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn12 and rpn-12

DIOPT Version :9

Sequence 1:	NP_648904.1	Gene:	Rpn12 / 39845	FlyBaseID:	FBgn0028693	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_496489.1	Gene:	rpn-12 / 174786	WormBaseID:	WBGene00004468	Length:	250	Species:	Caenorhabditis elegans

Alignment Length:	262	Identity:	86/262 - (32%)
Similarity:	144/262 - (54%)	Gaps:	13/262 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VESLYKELTAEWSKRPPNTVKCGQLLDQLKVALVKMAFLPTDGNDAQSSKKQLILARSVLEVAVE 68
            :.:.:|.|.|.|:|.|.:.|...:.|::    |.|:....:|.||.||:    :.::.:.|::|.
Worm     1 MSAAHKNLLAVWAKEPKDLVAVEKALNE----LTKVLSASSDLNDKQSA----LASKDLYEISVL 57

  Fly    69 HSVLSKDLLAFERYMAQLKCYYYDYAKIIGESESKYKLLGLNLLYLLSGNRVSDFHTELELLSVD 133
            .::|..|...|:.|:.|:..|   |......||:|:.:.||:|::||:.||:||||..||.:...
Worm    58 LAILKHDFETFDDYINQMHTY---YTMAPENSENKHLMTGLHLMFLLAANRLSDFHMLLEQIPQK 119

  Fly   134 VIQHNQFIRPILALEQYIMEGRYNKIFQAKSTVPVEVYSYFMDLLLETVRDEIGACIEKSYDKIS 198
            ....|.:|...:.:||.:|||.|||:...:..:|...|:.|:.::|:|:|.||...||||:..::
Worm   120 EQTSNAYISTPVRIEQSLMEGAYNKVVLTEKNIPSPFYTIFIRIMLDTIRREIATSIEKSFKVLT 184

  Fly   199 AKDAAKRLNLRVPDEIKAFGAKRQWKLEASGDYSFTDRSVKPKEL-LPSEELAEQVLSYARDLEM 262
            ||||...|.....:::|.||.:|:|.|:.. .|.|.....:.|.: |.:..:|.|.|.||:.||.
Worm   185 AKDATVMLLFDNDEQMKKFGQERKWHLDGE-RYVFEIEVAQEKPVNLDTVRVATQTLFYAKQLEQ 248

  Fly   263 IV 264
            ||
Worm   249 IV 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn12	NP_648904.1	CSN8_PSD8_EIF3K	119..230	CDD:287089	40/110 (36%)
rpn-12	NP_496489.1	CSN8_PSD8_EIF3K	87..218	CDD:287089	49/131 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158441
Domainoid	1	1.000	97	1.000	Domainoid score	I4543
eggNOG	1	0.900	-	-		E1_KOG3151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37686
Inparanoid	1	1.050	139	1.000	Inparanoid score	I3080
Isobase	1	0.950	-	0	Normalized mean entropy	S2152
OMA	1	1.010	-	-		QHG53806
OrthoDB	1	1.010	-	-		D1183195at2759
OrthoFinder	1	1.000	-	-		FOG0003512
OrthoInspector	1	1.000	-	-		otm14733
orthoMCL	1	0.900	-	-		OOG6_102164
Panther	1	1.100	-	-	LDO	PTHR12387
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1201
SonicParanoid	1	1.000	-	-		X2884
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790