DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smn and Smn1

DIOPT Version :9

Sequence 1:NP_001261954.1 Gene:Smn / 39844 FlyBaseID:FBgn0036641 Length:226 Species:Drosophila melanogaster
Sequence 2:NP_071954.2 Gene:Smn1 / 64301 RGDID:620755 Length:288 Species:Rattus norvegicus


Alignment Length:290 Identity:75/290 - (25%)
Similarity:115/290 - (39%) Gaps:101/290 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SDETNAAVWDDSLLVKTYDESVGLAREAL---------------ARRLADSTNKREEENAAAAEE 51
            ||:::  :|||:.|:|.||::|...:.||               |||.....||.:::||.|..:
  Rat    25 SDDSD--IWDDTALIKAYDKAVASFKHALKNGDMCETSDKPKGTARRKPAKKNKNQKKNATAPLK 87

  Fly    52 EAGEISATGGATSPEPVSFKVGDYARATY-VDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLL 115
            :                 :|.||...|.: .||..|...:.|::.::.|||:.|.||.|::|..|
  Rat    88 Q-----------------WKAGDKCSAVWSEDGCVYPATITSVDLKRETCVVVYTGYGNKEEQNL 135

  Fly   116 VDLL-PSWGKRVRREQFLIAKKDEDEQLSRPKASAGSHSKTPKSSRRSRI--------------- 164
            .||| |:.......||   ..::.:.|:|...:...|.|...|:..:|:.               
  Rat   136 SDLLSPTCEVANNTEQ---NTQENESQVSTDDSEHSSRSLRSKAHSKSKAAPWTSFLPPPPPVPG 197

  Fly   165 ----------------------------------SGGLVMPPMPPVPPMIVGQGDGAEQDFVAML 195
                                              ||..::||.||:.|..:...|.    ..:||
  Rat   198 AGLGPGKPGLRFNGPPPPPPPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDA----LGSML 258

  Fly   196 TAWYMSGYYTGLYQG----KKEASTTSGKK 221
            .:||||||:||.|.|    |||     |||
  Rat   259 ISWYMSGYHTGYYMGFRQNKKE-----GKK 283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmnNP_001261954.1 SMN 2..215 CDD:283622 72/282 (26%)
TUDOR 68..122 CDD:295375 21/55 (38%)
Smn1NP_071954.2 P1 (binding site for GEMIN2). /evidence=ECO:0000250 10..41 7/17 (41%)
SMN 24..280 CDD:399180 70/280 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 54..87 8/32 (25%)
Required for interaction with RPP20/POP7. /evidence=ECO:0000250 94..204 26/112 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..225 8/78 (10%)
P2 (binding site for SM B). /evidence=ECO:0000250 234..261 8/30 (27%)
Required for interaction with SYNCRIP. /evidence=ECO:0000250 273..288 7/16 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346778
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4327
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 75 1.000 Inparanoid score I5177
OMA 1 1.010 - - QHG47795
OrthoDB 1 1.010 - - D1316275at2759
OrthoFinder 1 1.000 - - FOG0006496
OrthoInspector 1 1.000 - - oto97628
orthoMCL 1 0.900 - - OOG6_108123
Panther 1 1.100 - - LDO PTHR13681
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X4739
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.770

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