DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smn and Smn1

DIOPT Version :9

Sequence 1:	NP_001261954.1	Gene:	Smn / 39844	FlyBaseID:	FBgn0036641	Length:	226	Species:	Drosophila melanogaster
Sequence 2:	XP_011242939.1	Gene:	Smn1 / 20595	MGIID:	109257	Length:	293	Species:	Mus musculus

Alignment Length:	274	Identity:	71/274 - (25%)
Similarity:	108/274 - (39%)	Gaps:	93/274 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SDETNAAVWDDSLLVKTYDESVGLAREAL---------------ARRLADSTNKREEENAAAAEE 51
            ||:::  :|||:.|:|.||::|...:.||               |||.....||.:::|
Mouse    25 SDDSD--IWDDTALIKAYDKAVASFKHALKNGDICETPDKPKGTARRKPAKKNKSQKKN------ 81

  Fly    52 EAGEISATGGATSPEPVSFKVGDYARATY-VDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLL 115
                      ||:|.. .:||||...|.: .||..|...:.||:.::.|||:.|.||.|.:|..|
Mouse    82 ----------ATTPLK-QWKVGDKCSAVWSEDGCIYPATITSIDFKRETCVVVYTGYGNREEQNL 135

  Fly   116 VDLL-PSWGKRVRREQFLIAKKDEDEQLSRPKASAGSHSKTPKSSRRSRI--------------- 164
            .||| |:.......||   ..::.:.|:|...:...|.|...|:..:|:.
Mouse   136 SDLLSPTCEVANSTEQ---NTQENESQVSTDDSEHSSRSLRSKAHSKSKAAPWTSFLPPPPPMPG 197

  Fly   165 -----------------------------------SGGLVMPPMPPVPPMIVGQGDGAEQDFVAM 194
                                               ||..::||.||:.|..:...|.    ..:|
Mouse   198 SGLGPGKPGLKFNGPPPPPPLPPPPFLPCWMPPFPSGPPIIPPPPPISPDCLDDTDA----LGSM 258

  Fly   195 LTAWYMSGYYTGLY 208
            |.:||||||:||.|
Mouse   259 LISWYMSGYHTGYY 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smn	NP_001261954.1	SMN	2..215	CDD:283622	71/274 (26%)
Smn	NP_001261954.1	TUDOR	68..122	CDD:295375	23/55 (42%)
Smn1	XP_011242939.1	SMN	24..273	CDD:310529	71/274 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843271
Domainoid	1	1.000	57	1.000	Domainoid score	I10902
eggNOG	1	0.900	-	-		E1_KOG4327
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I5270
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47795
OrthoDB	1	1.010	-	-		D1316275at2759
OrthoFinder	1	1.000	-	-		FOG0006496
OrthoInspector	1	1.000	-	-		oto94105
orthoMCL	1	0.900	-	-		OOG6_108123
Panther	1	1.100	-	-	LDO	PTHR13681
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3285
SonicParanoid	1	1.000	-	-		X4739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800