Protein Alignment Smn and smn1

DIOPT Version :10

• Sequence 1: NP_524112.1
• Gene: Smn / 39844
• FlyBaseID: FBgn0036641
• Length: 226
• Species: Drosophila melanogaster
• Sequence 2: NP_001093710.1
• Gene: smn1 / 100101724
• XenbaseID: XB-GENE-489160
• Length: 282
• Species: Xenopus tropicalis
• Alignment Length: 268
• Identity: 83/268 - (30%)
• Similarity: 121/268 - (45%)
• Gaps: 52/268 - (19%)

  Fly     2 SDETNAAVWDDSLLVKTYDESVGLAREALARRLADSTNKRE-EENAAAAEEEAGEISATGGATSP 65
            ||:::  :|||:.|:|.||::|...::||  :..|.|...| ||.....:.:..:.:.:....:.
 Frog    19 SDDSD--IWDDTALIKAYDKAVSSFKKAL--KNGDCTVSAEAEEKIPRTKRKNNKKNRSRKKCNA 79

  Fly    66 EPV-SFKVGDYARATY-VDGVDYEGAVVSINEEKGTCVLRYLGYENEQEVLLVDL-LP--SWGKR 125
            .|: .::|||...|.: .||..|...:.||:.:||||::.|.||.|.:|..|.|| .|  |..:.
 Frog    80 APLKKWRVGDTCNAIWSEDGNIYPATISSIDAKKGTCIVVYSGYGNSEEQSLADLRFPDTSEAES 144

  Fly   126 VRREQFLIAKKDE------DEQLSRPKASAGSHSKTPKSSR------------------------ 160
            .:|||......||      |.....|:.....:.:.||||:
 Frog   145 DQREQGQELNGDEHSTDESDRSSRSPQCKDSQNREIPKSSQWNGQFPPVPPPFMPGFGRHGEKLD 209

  Fly   161 --RSRISGG----LVMPPM-PPVPPMIVGQGDGAEQD--FVAMLTAWYMSGYYTGLYQGKKEAST 216
              ...:||.    |..||| ||.|||   ..|..|.|  ..:||.|||||||:||.|.|.|:...
 Frog   210 QAHPFLSGWPPPFLPGPPMIPPPPPM---SPDACEDDEALGSMLIAWYMSGYHTGYYLGLKQGRM 271

  Fly   217 TSGKKKTP 224
            .|...|:|
 Frog   272 ESSFGKSP 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smn	NP_524112.1	SMN	2..215	CDD:428716	80/257 (31%)
		Tudor_SMN	70..124	CDD:410469	23/57 (40%)
smn1	NP_001093710.1	SMN	17..282	CDD:428716	83/268 (31%)