DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf2 and Nxf1

DIOPT Version :9

Sequence 1:	NP_524111.3	Gene:	nxf2 / 39843	FlyBaseID:	FBgn0036640	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_058093.2	Gene:	Nxf1 / 53319	MGIID:	1858330	Length:	618	Species:	Mus musculus

Alignment Length:	505	Identity:	118/505 - (23%)
Similarity:	223/505 - (44%)	Gaps:	55/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 FYPCYYKYINTEHVFLVRNCFDQIAHLVNNCNLEMTIPTGDRIFRYYLRMNVS----TVKQHHVD 417
            |.|..:.|.||...|.|.:.  ..|..:...|.::......||   .:.:|.|    || |:.:.
Mouse   146 FNPIEFHYENTRAHFFVEDA--TTASALKGVNHKIQDRENRRI---SIIINASAPPYTV-QNELK 204

  Fly   418 PE--ECIQKAVSQCYVAQNRMLNLERFHSRECL--KDVMVSLSSPKILTYVLSVASRKFMTTCSE 478
            ||  |.::..:|:.|....:.|:|:...|...|  :::.|.|:....:...|.:.........|
Mouse   205 PEQIEQLKLIMSKRYDGNQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLS- 268

  Fly   479 IRLCHNKVLVLDG-AHVLGMMGCLRAVDLSHNWVQDLSSIHSLGNLPLKSLVLHGNKLCRNYRLP 542
            :.|..|::..||. :.::.....|:.::||.|.::....:..:..|.|:.|.|..|.:|.|:...
Mouse   269 LNLSSNRLYKLDDMSSIVQKAPNLKTLNLSGNELKTERELDKIKGLKLEELWLDRNPMCDNFGDQ 333

  Fly   543 SEYVRAVKEVFPQLTTLDGVDLQTNPGQSLQKNFL---CDTGAY-------ELVGAFLENYLREF 597
            |.|:.|::|.||:|..|||.:|.......::...:   | .|:|       .||..||:.|...:
Mouse   334 SSYISAIRERFPKLLRLDGHELPPPISFDVEAPTMLPPC-KGSYFGTENLKSLVLRFLQQYYVIY 397

  Fly   598 ENDEFRHNLYKYYSENSIFTLTCNYNVVQNHQTPKILQRLSKYNRHARNLRN-KDYSKASDGVFF 661
            ::.:.:..||.|:.     ...|:.::..|.|.| :.:.|::|.:.:||::. |:.::....:..
Mouse   398 DSGDRQGLLYAYHD-----GACCSLSIPYNPQNP-VRKNLAEYVKDSRNVKKLKEPTQRFRLLKH 456

  Fly   662 GCTYIVEILLQLPRVTHDFHSLQTDVMHYNGKGAVIYVAGLLRDEPPSTRNGHGSKTDIGGVLLG 726
            ....:|..|.:||:..||.::...|:...........|.|:.::....:|:.          |..
Mouse   457 TRLNVVAFLNELPKTQHDVNAFVVDISAQTSTLLCFSVNGVFKEVDGKSRDS----------LRA 511

  Fly   727 FSRQFVVTFDEANLGLGKRARRLKIANERLHITNPSKTAIRNAFSVNFPDPSERQAEEDSLDVKD 791
            |:|.|:.. ..:|.|       |.|.|:.|.:.|.|...|:.||:::.|.||  .:...:|..:.
Mouse   512 FTRTFIAV-PASNSG-------LCIVNDELFVRNASPEEIQRAFAMSAPTPS--SSPVPTLSPEQ 566

  Fly   792 HKLL-LFQEVTGLISTWVTSIVEEADWDFERALKLFIQKNADHEIPDLAF 840
            .::| .|...:|:...|....:::.:||:.|:.:.|....|..|||::||
Mouse   567 QEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTLLKAKGEIPEVAF 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf2	NP_524111.3	leucine-rich repeat	434..474	CDD:275382	7/41 (17%)
		leucine-rich repeat	475..500	CDD:275382	5/25 (20%)
		leucine-rich repeat	501..524	CDD:275382	4/22 (18%)
		leucine-rich repeat	525..555	CDD:275382	11/29 (38%)
		TAP_C	779..841	CDD:197882	15/63 (24%)
Nxf1	NP_058093.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113
		Interaction with ALYREF/THOC4 and LUZP4. /evidence=ECO:0000250\|UniProtKB:Q9UBU9	2..197		13/55 (24%)
		RNA-binding (RBD). /evidence=ECO:0000250	2..117
		Minor non-specific RNA-binding. /evidence=ECO:0000250	2..59
		Major non-specific RNA-binding. /evidence=ECO:0000250	60..117
		RNA binding. /evidence=ECO:0000250	60..117
		Nuclear localization signal. /evidence=ECO:0000250	66..99
		Nuclear export signal. /evidence=ECO:0000250	82..109
		Tap-RNA_bind	115..197	CDD:286271	13/55 (24%)
		leucine-rich repeat	223..265	CDD:275382	7/41 (17%)
		LRR_8	264..326	CDD:290566	14/62 (23%)
		LRR 1	265..290		5/25 (20%)
		leucine-rich repeat	266..291	CDD:275382	5/25 (20%)
		LRR_4	290..328	CDD:289563	9/37 (24%)
		LRR 2	291..314		4/22 (18%)
		leucine-rich repeat	292..315	CDD:275382	4/22 (18%)
		LRR 3	315..342		9/26 (35%)
		leucine-rich repeat	316..346	CDD:275382	11/29 (38%)
		LRR 4	343..370		7/26 (27%)
		NTF2	381..537	CDD:238403	37/179 (21%)
		TAP_C	555..617	CDD:197882	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R710
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.830