DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf2 and sbr

DIOPT Version :9

Sequence 1:	NP_524111.3	Gene:	nxf2 / 39843	FlyBaseID:	FBgn0036640	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	138/637 - (21%)
Similarity:	241/637 - (37%)	Gaps:	162/637 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 GARIDTNNMWKLPEFENSQHWHAFMIPDPSHEFNQEVFFDFFFIRLDPTLSNFYPCYYKYINTEH 369
            |:.|......||  ..||..|:...:.: :..:.:|.........:.|.:  |.|.|::
  Fly    95 GSPIPRGKFGKL--MPNSFGWYQVTLQN-AQIYEKETLLSALLAAMSPHV--FIPQYWR------ 148

  Fly   370 VFLVRNCF----------DQIAHLVNNCNLEMTIPTGDRIFRYYLRMNVSTVKQHHVDP--EECI 422
              :.|||.          ::|.||..|.:|    |.|.|:.. .:|..:..|.   :|.  :|.:
  Fly   149 --VERNCVIFFTDDYEAAERIQHLGKNGHL----PDGYRLMP-RVRSGIPLVA---IDDAFKEKM 203

  Fly   423 QKAVSQCYVAQNRMLNLERFHSRECLKDVMVSLSSPKILTYVLSVASRKFMTTCSEIRLCHN--- 484
            :..:::.|..|.:.|:|.|||:...||.|...|....::...:.:             :|.|
  Fly   204 KVTMAKRYNIQTKALDLSRFHADPDLKQVFCPLFRQNVMGAAIDI-------------MCDNIPD 255

  Fly   485 -KVLVLDGAHVLGM---------MGCLRAVDLSHNWVQDLSSIHSLGNLPLKSLVLHGNKLCRNY 539
             :.|.|:...:..|         :..|:.:.|..|.:..|:.:..|.||.:..|||..|.....|
  Fly   256 LEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELVLKNNPCRSRY 320

  Fly   540 RLPSEYVRAVKEVFPQLTTLDGVDLQ-------TNPGQSLQ--KNFLCDTGAYELVGAFLENYLR 595
            :...:::..|:..||:|..|||..|:       :..|:.|:  .::|||....|:|..||:.|.|
  Fly   321 KDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQGRLLETKASYLCDVAGAEVVRQFLDQYFR 385

  Fly   596 EFENDEFRHNLYKYYSENSIFTLTCNYNVVQNHQTPKILQ--RLS---KYNRHARNLRNKDYSKA 655
            .|::.. |..|...|.|.::.:::          .|...|  ||:   |:||:.|.|.|.:.::.
  Fly   386 IFDSGN-RQALLDAYHEKAMLSIS----------MPSASQAGRLNSFWKFNRNLRRLLNGEENRT 439

  Fly   656 SDGVFFGCTYIVEILLQLPRVTHDFHSLQTDVMHYNGKGAVIYVAGLLRDEPPSTRNGHGSKT-D 719
            .: :.:|....|..|.:.|:..||..:...|:..||....|..|.||.::....|.|....:. |
  Fly   440 RN-LKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASMELYD 503

  Fly   720 IGGVLLGFSRQFVVTFDEANLGLGKRARRLKIANERLHITNPSKTAIR----------------N 768
            :    ..|:|.:||.  ..|.|       ..|.||.:.|||.:...:|                .
  Fly   504 V----RHFARTYVVV--PQNNG-------FCIRNETIFITNATHEQVREFKRSQHQPAPGAMPST 555

  Fly   769 AFSVNFP---------------------------DPSERQ------------------AEEDSLD 788
            :.:|..|                           ||....                  |:::|..
  Fly   556 SSAVTSPQAGAAAGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTK 620

  Fly   789 VKDHKLLLFQEVTGLISTWVTSIVEEADWDFERALKLFIQKNADHEIPDLAF 840
            ::..:.:..|....:|  |....:||.:|||..|..:|.:...:::||..||
  Fly   621 MQMIEAMSAQSQMNVI--WSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAF 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf2	NP_524111.3	leucine-rich repeat	434..474	CDD:275382	9/39 (23%)
		leucine-rich repeat	475..500	CDD:275382	5/37 (14%)
		leucine-rich repeat	501..524	CDD:275382	6/22 (27%)
		leucine-rich repeat	525..555	CDD:275382	7/29 (24%)
		TAP_C	779..841	CDD:197882	16/80 (20%)
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	18/94 (19%)
		leucine-rich repeat	215..255	CDD:275382	11/52 (21%)
		LRR_RI	<223..341	CDD:238064	27/130 (21%)
		LRR_8	256..315	CDD:290566	13/58 (22%)
		LRR_4	256..298	CDD:289563	7/41 (17%)
		leucine-rich repeat	256..281	CDD:275382	3/24 (13%)
		leucine-rich repeat	282..305	CDD:275382	6/22 (27%)
		leucine-rich repeat	306..336	CDD:275382	7/29 (24%)
		NTF2	372..531	CDD:238403	47/183 (26%)
		Big_3_5	<578..>614	CDD:293246	2/35 (6%)
		TAP_C	609..671	CDD:197882	16/64 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D442228at33208
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R710
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.880