DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf2 and mex67

DIOPT Version :9

Sequence 1:	NP_524111.3	Gene:	nxf2 / 39843	FlyBaseID:	FBgn0036640	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_595996.1	Gene:	mex67 / 2540727	PomBaseID:	SPBC1921.03c	Length:	596	Species:	Schizosaccharomyces pombe

Alignment Length:	476	Identity:	113/476 - (23%)
Similarity:	193/476 - (40%)	Gaps:	64/476 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 NVS-TVKQHHVDPEECIQKAVSQCYVAQNRMLNLERFHSRECLKDVMV---SLSSPKILTYVLSV 467
            ||| |:.|...:..|.:::.:...|....:.|:|........||.:.:   :.:..|:...::.|
pombe   144 NVSKTLPQSTNETIEKLRQFLQTRYQPATKFLDLGNLQQDPLLKQMGILAEASTKSKMFPALMKV 208

  Fly   468 ASRKFMTTCSEIRLCHNKVLVLDGAHVLGM-MGCLRAVDLSHNWVQDLSSIHSLG---NLP-LKS 527
            ||..|....| :.|..|.:..:.....|.. ...|..:.|::|.:..||.:....   .|| |:.
pombe   209 ASLNFPDVIS-VSLSDNNLQSVTAVTTLAQTWPKLLNLSLANNRITSLSDLDPWSPKTKLPELQE 272

  Fly   528 LVLHGNKLCRNY-RLPSEYVRAVKEVFPQLTTLDG--VDLQTNPGQS-----LQKNFLCDTGAYE 584
            |||.||.:...: ....:|.|.:...||:|..|||  ::.:....||     :.::|.......:
pombe   273 LVLVGNPIVTTFANRAMDYQREMVSRFPKLRLLDGNSINSEIIASQSTVPFPVYQSFFDKVETEQ 337

  Fly   585 LVGAFLENYLREFENDEFRHNLY-KYYSENSIFTLTCN-YNVVQNHQTPKILQRLSKYNRHARNL 647
            :|.:||..:.:.:  ||.|..|. :.||.|:.|:::.| .||..|.......::...|...:|||
pombe   338 IVNSFLAAFFKGW--DENRSALVNQLYSPNATFSISLNASNVRTNFSQKTDTKKWGAYKMKSRNL 400

  Fly   648 RNKDYSKASDG-VFFGCTYIVEILLQLPRVTHDFHSLQTDVMH-YN------GKGAVIYVAGLLR 704
            ......|.|.. :|.|...|...:..||...||.......|.. :|      |....|.|.|..
pombe   401 LYSQSQKESKSRLFNGHEEISNAVKSLPATAHDLSDRSQWVFDGWNLVLPSVGAAIKIVVHGQF- 464

  Fly   705 DEPPSTRNGHGSKTDIGGVLLGFSRQFVVTFDEANLGLGKRARRLKIANERLHITN--------P 761
            :||.:.|                   .:.:||...|.|...:..:.|.|:.|.|.:        |
pombe   465 EEPQNKR-------------------LLRSFDRTLLILPGGSTGILIINDLLVIRSFAGSLGWLP 510

  Fly   762 SKTAIR---NAFSVNFPDPS---ERQAEEDSLDVKDHKLLLFQEVTGLISTWVTSIVEEADWDFE 820
            .::::|   ||.|.:...||   :.:.|:..||.:...:|..:..|||...:.....|:.:||:.
pombe   511 GQSSVRTSNNAMSASASKPSDIVQPRPEQAMLDTRQQIVLKIKAETGLNDYYAHMCCEQNNWDYN 575

  Fly   821 RALKLFIQKNADHEIPDLAFA 841
            .||..|::..:.:.||..||:
pombe   576 SALASFLELKSRNVIPAEAFS 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf2	NP_524111.3	leucine-rich repeat	434..474	CDD:275382	9/42 (21%)
		leucine-rich repeat	475..500	CDD:275382	4/25 (16%)
		leucine-rich repeat	501..524	CDD:275382	5/25 (20%)
		leucine-rich repeat	525..555	CDD:275382	9/30 (30%)
		TAP_C	779..841	CDD:197882	16/61 (26%)
mex67	NP_595996.1	leucine-rich repeat	172..215	CDD:275382	9/42 (21%)
		leucine-rich repeat	216..241	CDD:275382	4/25 (16%)
		LRR_8	218..280	CDD:290566	17/62 (27%)
		LRR_4	240..>280	CDD:289563	13/39 (33%)
		leucine-rich repeat	242..269	CDD:275382	6/26 (23%)
		leucine-rich repeat	270..301	CDD:275382	9/30 (30%)
		TAP_C	535..595	CDD:197882	15/59 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R710
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900