DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf2 and Nxf3

DIOPT Version :9

Sequence 1:	NP_524111.3	Gene:	nxf2 / 39843	FlyBaseID:	FBgn0036640	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_030107204.1	Gene:	Nxf3 / 245610	MGIID:	2685230	Length:	567	Species:	Mus musculus

Alignment Length:	663	Identity:	133/663 - (20%)
Similarity:	242/663 - (36%)	Gaps:	190/663 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RGNKIKSAERLCRALEQFRARELLLENNPI-------------VKISNFPANIK-----SLESNF 277
            |.::.....|..|....|:.|.|   |:|.             ..:||.|.:.:     .:.|.:
Mouse     3 RSSETNPLRRRMRCRRIFQQRFL---NSPAHVSDTVHTSFYQQPAMSNPPMHTRRYTPYGIPSRY 64

  Fly   278 ELVDGKPFNMLHKIFSPLDVEIDLEVDGARIDTNNMWKLPEFENSQHWHAFMIPDPSHEFNQEVF 342
            :.|..:.:|         ..::::| .|::.....|.:..:.:.|::|....||
Mouse    65 QRVSVQKWN---------QTDVNME-GGSKPPERKMQRDKQDDTSENWFKVTIP----------- 108

  Fly   343 FDFFFIRLDPT-LSN---------FYPCYYKYINTEHVFLVRNCFDQIAHLVNNCNLEMTIPTGD 397
               |.|:.|.. |.|         |.|..:.|...:..|.|.|  ..||.::...:.::...|.:
Mouse   109 ---FGIKYDKKWLLNLIQSQCSIPFTPVQFHYEKMQAHFFVDN--PNIAFMLKAISDKILDETDN 168

  Fly   398 RIFRYYLRMNVSTVKQHHVDPEECIQK-------AVSQCYVAQNRMLNLERFHSRECLKDVMVSL 455
            :|..:     :|...:.|...|..::|       ...||..:| |:||.:|....:   |:|...
Mouse   169 KISIF-----ISPCDEPHSVTELKLEKMDHTMLTTNQQCATSQ-RVLNRQRLPFDQ---DLMTRP 224

  Fly   456 SSPKILTYVLSVASRKFMTTCSEIRLCHNKVLVLDGAHVLGMMGCLRAVDLSHNWVQDLSSIHSL 520
            :.       |::..|::||....|                            |.  :|::.::|.
Mouse   225 TD-------LALVPRRYMTPSLSI----------------------------HK--EDMTQVNSE 252

  Fly   521 GNLPLKSLVLHG---NKLCRNY-----RLP--SEYVRAVKEVFPQLTTLDGVDLQTNPGQSLQKN 575
            |.:    ..:|.   .|:|.:.     .:|  |..:.::.|:||:|.:||        ||...|.
Mouse   253 GEV----AKVHAPDLEKICADQSSLSTTMPDKSSNINSILELFPKLLSLD--------GQESHKP 305

  Fly   576 FLCDTGAYELVGA-----------------FLENYLREFENDEFRHNLYKYYSENSIFTLTCNYN 623
            .||....::.:.|                 ||:.|...::|.: |..|...|...:.||||..::
Mouse   306 TLCGPEDHKTLSACKEIFFGSESIKTMVLQFLKQYYFIYDNGD-RQGLLNAYHPEACFTLTIPFS 369

  Fly   624 VVQNHQTPKILQRLSKYNRHARNLR-NKD-YSKASDGVFFGCTYIVEILLQLPRVTHDFHSLQTD 686
            .:.     ..:..|.:|.:.:||:: .|| |.:........|. |:..|..||:..||..|...|
Mouse   370 SID-----LSMNSLCEYFKFSRNMKILKDPYMRRQLLKHKKCD-IIHFLRTLPKTQHDLTSFVVD 428

  Fly   687 VMHYNGKGAVIYVAGLLRDEPPSTRNGHGSKTDIGGVLLGFSRQFVVTFDEANLGLGKRARRLKI 751
            :.....|.....|:||.::...|.:          |.:..|:|.||||.|.::        .|.|
Mouse   429 ICLQTEKMLCFSVSGLFKEVDNSAQ----------GCMHAFTRIFVVTHDNSS--------ELCI 475

  Fly   752 ANERLHITN----PS-KTAIRNAFSVNFPDPSERQAEEDSLDVKDHKLLLFQEVTGLISTWVTSI 811
            .|::|.:||    || .|.:..:.:...|..|:.|.|         .:..|...:|:........
Mouse   476 INDKLSVTNVHEVPSASTPVATSSTSYLPSFSQDQQE---------MVPTFCAQSGVNVDRSQKS 531

  Fly   812 VEEADWDFERALK 824
            :.:..|::.||::
Mouse   532 LHDDQWNYNRAIQ 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf2	NP_524111.3	leucine-rich repeat	434..474	CDD:275382	8/39 (21%)
		leucine-rich repeat	475..500	CDD:275382	1/24 (4%)
		leucine-rich repeat	501..524	CDD:275382	4/22 (18%)
		leucine-rich repeat	525..555	CDD:275382	7/39 (18%)
		TAP_C	779..841	CDD:197882	7/46 (15%)
Nxf3	XP_030107204.1	Tap-RNA_bind	99..181	CDD:370331	20/102 (20%)
		leucine-rich repeat	206..244	CDD:275382	13/78 (17%)
		leucine-rich repeat	263..293	CDD:275382	6/29 (21%)
		NTF2_like	328..484	CDD:385413	44/180 (24%)
		TAP_C	499..561	CDD:197882	9/55 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D442228at33208
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810