DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf2 and NXF1

DIOPT Version :9

Sequence 1:	NP_524111.3	Gene:	nxf2 / 39843	FlyBaseID:	FBgn0036640	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_006353.2	Gene:	NXF1 / 10482	HGNCID:	8071	Length:	619	Species:	Homo sapiens

Alignment Length:	525	Identity:	122/525 - (23%)
Similarity:	222/525 - (42%)	Gaps:	95/525 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 FYPCYYKYINTEHVFLVRNCFDQIAHLVNNCNLEMTIPTGDRIFRYYLRMNV---STVKQH---- 414
            |.|..:.|.||...|.|.:.  ..|..:...|.::.    ||..|   |:::   |:...|
Human   147 FTPIEFHYENTRAQFFVEDA--STASALKAVNYKIL----DRENR---RISIIINSSAPPHTILN 202

  Fly   415 HVDPE--ECIQKAVSQCYVAQNRMLNLERFHSRECL--KDVMVSLSSPKILTYVLSVASRKFMTT 475
            .:.||  |.::..:|:.|....:.|:|:...|...|  :::.|.|:....:...|.:........
Human   203 ELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPEL 267

  Fly   476 CSEIRLCHNKVLVLDG-AHVLGMMGCLRAVDLSHNWVQDLSSIHSLGNLPLKSLVLHGNKLCRNY 539
            .| :.|.:|::..||. :.::.....|:.::||.|.::....:..:..|.|:.|.|.||.||..:
Human   268 LS-LNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTF 331

  Fly   540 RLPSEYVRAVKEVFPQLTTLDGVDL-----------QTNPGQSLQKNFLCDTGAY-------ELV 586
            |..|.|:.|::|.||:|..|||.:|           .|.|.        | .|:|       .||
Human   332 RDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPP--------C-KGSYFGTENLKSLV 387

  Fly   587 GAFLENYLREFENDEFRHNLYKYYSENSIFTLTCNYNVVQNHQTPKILQRLSKYNRHARNLRN-K 650
            ..||:.|...:::.: |..|...|.:.:..:|:..: :.||    .....|::|.:.:||::. |
Human   388 LHFLQQYYAIYDSGD-RQGLLDAYHDGACCSLSIPF-IPQN----PARSSLAEYFKDSRNVKKLK 446

  Fly   651 D---------YSKASDGVFFGCTYIVEILLQLPRVTHDFHSLQTDVMHYNGKGAVIYVAGLLRDE 706
            |         :::.:         :|..|.:||:..||.:|...|:...........|.|:.::.
Human   447 DPTLRFRLLKHTRLN---------VVAFLNELPKTQHDVNSFVVDISAQTSTLLCFSVNGVFKEV 502

  Fly   707 PPSTRNGHGSKTDIGGVLLGFSRQFVVTFDEANLGLGKRARRLKIANERLHITNPSKTAIRNAFS 771
            ...:|:.          |..|:|.|:.. ..:|.|       |.|.|:.|.:.|.|...|:.||:
Human   503 DGKSRDS----------LRAFTRTFIAV-PASNSG-------LCIVNDELFVRNASSEEIQRAFA 549

  Fly   772 VNFPDPSERQAEEDSLDVKDHKLL-LFQEVTGLISTWVTSIVEEADWDFERALKLFIQKNADHEI 835
            :..|.||  .:...:|..:..::| .|...:|:...|....:::.:||:.|:.:.|....|..||
Human   550 MPAPTPS--SSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEI 612

  Fly   836 PDLAF 840
            |::||
Human   613 PEVAF 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf2	NP_524111.3	leucine-rich repeat	434..474	CDD:275382	7/41 (17%)
		leucine-rich repeat	475..500	CDD:275382	5/25 (20%)
		leucine-rich repeat	501..524	CDD:275382	4/22 (18%)
		leucine-rich repeat	525..555	CDD:275382	13/29 (45%)
		TAP_C	779..841	CDD:197882	15/63 (24%)
NXF1	NP_006353.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85
		RNA-binding (RBD)	2..118
		Minor non-specific RNA-binding	2..60
		Major non-specific RNA-binding	61..118
		Nuclear localization signal	67..100
		Nuclear export signal	83..110
		Tap-RNA_bind	116..198	CDD:401194	14/59 (24%)
		noncanonical RNP-type RNA-binding (RBD) domain	121..198		14/59 (24%)
		leucine-rich repeat (LRR) domains	199..371		42/172 (24%)
		LRR	<200..>327	CDD:227223	27/127 (21%)
		leucine-rich repeat	224..266	CDD:275382	7/41 (17%)
		LRR_8	265..327	CDD:404697	15/62 (24%)
		leucine-rich repeat	267..292	CDD:275382	5/25 (20%)
		leucine-rich repeat	293..316	CDD:275382	4/22 (18%)
		leucine-rich repeat	317..347	CDD:275382	13/29 (45%)
		NTF2	382..538	CDD:238403	38/188 (20%)
		TAP_C	556..618	CDD:197882	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D442228at33208
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R710
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.940