DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nxf2 and LOC100490733

DIOPT Version :9

Sequence 1:	NP_524111.3	Gene:	nxf2 / 39843	FlyBaseID:	FBgn0036640	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_004914856.2	Gene:	LOC100490733 / 100490733	-ID:	-	Length:	658	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	131/597 - (21%)
Similarity:	227/597 - (38%)	Gaps:	99/597 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PLDVEIDLEVD-----GARIDTNN--MWKLPEFENSQHWHAFMIPDPSHEFNQEVFFDF------ 345
            ||.::...|::     |:.::.:|  :::... :|:|.|....|| ...::|::...:.
Frog   107 PLSLDESNEIEDPYEGGSHLNPSNGQLYRAKN-DNTQVWFKITIP-YGKDYNKDWLLNAIREECG 169

  Fly   346 FFIRLDPTLSNFYPCYYKYINTEHVFLVRNCFDQIAHLVNNCNLEMTIPTGDRIFRYYLRMNVST 410
            .|.|.:         .:.|:..:.||.|    |:.|......|....| ..|:.|:..:.:..|.
Frog   170 LFFRAE---------QFHYVKKKAVFFV----DKFATAKALLNASRKI-QADQYFKIVINVTPSM 220

  Fly   411 VKQH------HVDPE----------ECIQKAVSQCYVAQNRMLNL-------ERFHSRECLKDVM 452
            .:.|      |.|.:          .|||..:.:.|..:...|:|       |...:.:||
Frog   221 YRHHGNPTLCHRDAKMGSLCPGDSLYCIQACLQKRYDDRTASLDLSNLSIDPELQSTNKCL---- 281

  Fly   453 VSLSSPKILTYVLSVASRKFMTTCSEIRLCHNKVLVL-DGAHVLGMMGCLRAVDLSHNWVQDLSS 516
             .|:.......:|.:.:..|....| :.|.:|.:..| |.:.:..:...|::::||:|.:.....
Frog   282 -CLNQASDAELILQLIAEHFPQLLS-LDLSYNNLSSLTDFSGLSALAPQLQSMNLSYNQICQAQE 344

  Fly   517 IHSLGNLPLKSLVLHGNKLCRNYRLPSEYVRAVKEVFPQLTTLDGVDLQTNPG----------QS 571
            |:.|..|.||.|.|.||....:....|.|.|.|...||.:..|||...:  ||          ..
Frog   345 INVLHKLELKELWLEGNPFLASLESTSTYYRIVMNHFPSVQILDGHFFK--PGCFFGKVPRSLPQ 407

  Fly   572 LQKNFLCDTGAYELVGAFLENYLREFENDEFRHNLYKYYSENSIFTLTCNYNVVQNHQTPKI-LQ 635
            ::.:|..:......:..|:..|...:::.: |..|...|.||    ..|::: :.|...|.| ::
Frog   408 IKGSFFVNEDLRAFLVPFVSRYFTIYDSTQ-RQQLLPLYHEN----CCCSFS-LPNVLLPHICVE 466

  Fly   636 RLSKYNRHARN-LRNKDYSKASDGVFFGCTYIVEILLQLPRVTHDFHSLQTDVMHYNGKGAVIYV 699
            :..:|.:..|| ||.|..:.....:.:....:|..|..|||..||..|...||...........|
Frog   467 QAKEYLKENRNLLRVKRAALRQQLMKYNRLQVVGFLCNLPRTEHDLSSFTLDVWFQTPSLIGFSV 531

  Fly   700 AGLLRDEPPSTRNGHGSKTDIGGVLLGFSRQF-VVTFDEANLGLGKRARRLKIANERLHITNPSK 763
            ||:.::|.|..:.          :...|.|.| :|...||         ..:|.|::|.|.|...
Frog   532 AGIFKEESPKWKK----------LCRSFRRSFLIVPAMEA---------CAQILNDQLVIINSYV 577

  Fly   764 TAIRNAFSVNFPDPSERQAEEDSLDVKDHKLLLFQEVTGLISTWVTSIVEEADWDFERALKLFIQ 828
            ....:......|||....:.....|.....|..|.|.||:...|....:|:.:|:.|:|..:|..
Frog   578 DQYEDKCGPASPDPGSPGSNVALCDGNMAVLRNFSESTGMKVEWALKCLEDNNWNVEQAQDVFSL 642

  Fly   829 KNADHEIPDLAF 840
            ......||..||
Frog   643 LKEKGTIPQDAF 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nxf2	NP_524111.3	leucine-rich repeat	434..474	CDD:275382	8/46 (17%)
		leucine-rich repeat	475..500	CDD:275382	5/25 (20%)
		leucine-rich repeat	501..524	CDD:275382	6/22 (27%)
		leucine-rich repeat	525..555	CDD:275382	11/29 (38%)
		TAP_C	779..841	CDD:197882	16/62 (26%)
LOC100490733	XP_004914856.2	Tap-RNA_bind	144..220	CDD:401194	16/90 (18%)
		LRR	258..>362	CDD:227223	25/109 (23%)
		leucine-rich repeat	260..302	CDD:275382	8/46 (17%)
		LRR_8	<299..339	CDD:404697	10/40 (25%)
		leucine-rich repeat	303..328	CDD:275382	5/25 (20%)
		leucine-rich repeat	329..352	CDD:275382	6/22 (27%)
		leucine-rich repeat	353..383	CDD:275382	11/29 (38%)
		NTF2_like	425..574	CDD:415585	42/173 (24%)
		UBA_TAP-C	606..654	CDD:270527	13/47 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D442228at33208
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020