DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp1 and Mipp2

DIOPT Version :9

Sequence 1:	NP_001287082.1	Gene:	Mipp1 / 39841	FlyBaseID:	FBgn0026061	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_511055.1	Gene:	Mipp2 / 31544	FlyBaseID:	FBgn0026060	Length:	453	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	141/471 - (29%)
Similarity:	228/471 - (48%)	Gaps:	61/471 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LILLLLPL---VAIAQDDYCFSKDTSRLQTRQFSSKTAYQIVKGTD-IDKQYLVPGCQPQKMWIF 64
            |.||||..   |.::::..|...:.:.::.| .|:||.|:.:...| ...:|  .||.|.::|..
  Fly     8 LFLLLLHFFVGVTLSEEGECRRLNRADIEGR-LSTKTPYRAIANYDETPPKY--AGCHPTRIWTI 69

  Fly    65 HRHGTRLPKKSMINKA-SRVAELRDLIINNYQVARTKPETDALCQTDLIAIKLWKWNSSITPDME 128
            .|||||.|.:|:|.:| :|::|::..|::     :|||   .:|..:|..::.|.|......:.|
  Fly    70 IRHGTRNPSESVILQAQNRLSEIKKRILD-----QTKP---PICTAELEKLRQWHWMHLNATEDE 126

  Fly   129 EYLTAQGYEDLRGTAKLYQRYYPTVLTANYNDTYYQFRHTDTQRTTESFKAFAEGLFGSQNAAHP 193
            :.|.|:|.::|...|:..||.:|.:|...||..:|.|::|.||||.:|.::||.|||| ::..|.
  Fly   127 KLLVAEGEDELIELAERMQRRFPDLLPELYNPEWYYFKYTATQRTLKSAESFATGLFG-RHRIHT 190

  Fly   194 VEIP---KQDLLLRPYDYCSSFKN---------VNYKDEGSEYYKFHQSKLYNDTLADI--STRL 244
            |..|   .:|.:||.|..|..:|.         ||.:       :|.........:..:  ||||
  Fly   191 VRYPPPLHEDPVLRFYKGCGKWKTDVDKNPETLVNAR-------RFLAEPQMQSAVEQVRSSTRL 248

  Fly   245 GFLYTLEEADIKLMYDMCRYEQAWNVDRN---------SVWCGAFLPEQITVFEYLEDLKYYYGS 300
            .   .|:..|::|||.:|.:|.||:..|:         ||||..|....:...|:.|||:||:..
  Fly   249 P---DLQPEDVQLMYTVCAFETAWHRPRHDSGSKSSYESVWCNFFDVAALEALEFFEDLEYYWND 310

  Fly   301 GYGFPENAHLNCRLVQDLLTHLSNPVS-----PHVVAHFGHSTGLLTLLTALGIQKDDIKLRADN 360
            |||:.....:.|..:.|:...:|:...     .:...:|.||..||.||..||:.:|:..|...:
  Fly   311 GYGYELTHRIACPAIADMFAAISSSEETRQRRANATLYFTHSGTLLKLLAHLGLARDNKPLTHKH 375

  Fly   361 YDSLTSRRWKSSLIDPFAANFVAVKYDCPADLDREKVVFFLNQQAVQLDWC--SVGLCKWSDVLE 423
            :.|  .|.|::|.||.||.|...::|||  |....:|:....::.|:|..|  ...||..:.:..
  Fly   376 FAS--ERLWRTSQIDAFATNLAFLRYDC--DKGNPQVLVLHQERVVRLPGCPQDKDLCPLATLRR 436

  Fly   424 KYKTIADADCGEYYCR 439
            .|....|....|..||
  Fly   437 IYANSVDHCDREKMCR 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp1	NP_001287082.1	HP_HAP_like	129..402	CDD:132717	93/300 (31%)
Mipp2	NP_511055.1	HP	68..351	CDD:299704	89/301 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468926
Domainoid	1	1.000	93	1.000	Domainoid score	I2558
eggNOG	1	0.900	-	-		E1_KOG1382
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I1990
Isobase	1	0.950	-	0	Normalized mean entropy	S5846
OMA	1	1.010	-	-		QHG55377
OrthoDB	1	1.010	-	-		D1046588at2759
OrthoFinder	1	1.000	-	-		FOG0004136
OrthoInspector	1	1.000	-	-		mtm6348
orthoMCL	1	0.900	-	-		OOG6_101372
Panther	1	1.100	-	-	P	PTHR20963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3401
	13	12.760