DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp1 and pho4

DIOPT Version :9

Sequence 1:	NP_001287082.1	Gene:	Mipp1 / 39841	FlyBaseID:	FBgn0026061	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_595181.1	Gene:	pho4 / 2540606	PomBaseID:	SPBC428.03c	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	397	Identity:	100/397 - (25%)
Similarity:	172/397 - (43%)	Gaps:	52/397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CQPQKMWIFHRHGTRLPKKSMINKASRVAELRDL-IINNYQVARTKPETDALCQTDLIAIKLWKW 119
            |..:::.:..|||:|.|...  :.|:.|:..:.: |..|..:..:.|...:..:..|..:|  .|
pombe    58 CAIKQVHLLQRHGSRNPTGD--DTATDVSSAQYIDIFQNKLLNGSIPVNFSYPENPLYFVK--HW 118

  Fly   120 NSSITPDMEEYLTAQGYEDLRGTAK-LYQRYYPTVLTANYNDTYYQFRHTDTQRTTESFKAFAEG 183
            ...|..:..:.|::.|..:|....: :::|||..     ::...|.......:|..:|.:.|:.|
pombe   119 TPVIKAENADQLSSSGRIELFDLGRQVFERYYEL-----FDTDVYDINTAAQERVVDSAEWFSYG 178

  Fly   184 LFGS--QNAAHPVEIPKQDLL----LRPYDYCSSFKNVNYKDEGSEYYKFHQSKLYNDTLADIST 242
            :||.  ||..:.:.:|:.|..    |..|..|..:::.|..:..:|  ..|.| ..|..|..|:.
pombe   179 MFGDDMQNKTNFIVLPEDDSAGANSLAMYYSCPVYEDNNIDENTTE--AAHTS-WRNVFLKPIAN 240

  Fly   243 RLGFL----YTLEEADIKLMYDMCRYEQAWNVDRNSVWCGAFLPEQITVFEYLEDLKYYYGSGYG 303
            ||...    |.|..:|::.:|.:|.||.|  :..||.:|..|.|.:...|||..||.|.|   :|
pombe   241 RLNKYFDSGYNLTVSDVRSLYYICVYEIA--LRDNSDFCSLFTPSEFLNFEYDSDLDYAY---WG 300

  Fly   304 FPEN--------AHLNCRLVQDLLTHLSNPVSPHVVAHFGHSTGLLTLLTALGIQKD---DIKLR 357
            .|.:        |::| .|..:|...::|.....|...|.|.:.::.:..|||...|   :..|.
pombe   301 GPASEWASTLGGAYVN-NLANNLRKGVNNASDRKVFLAFTHDSQIIPVEAALGFFPDITPEHPLP 364

  Fly   358 ADNYDSLTSRRWKSSLIDPFAANFVAVKYDCPADLDREKVVFFLNQQAVQLDWC-------SVGL 415
            .|.  ::.:...|:|...|||.|.:...:.| :| ::..|...:|||...|..|       |.||
pombe   365 TDK--NIFTYSLKTSSFVPFAGNLITELFLC-SD-NKYYVRHLVNQQVYPLTDCGYGPSGASDGL 425

  Fly   416 CKWSDVL 422
            |:.|..|
pombe   426 CELSAYL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp1	NP_001287082.1	HP_HAP_like	129..402	CDD:132717	74/294 (25%)
pho4	NP_595181.1	His_Phos_2	60..405	CDD:278743	88/366 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I2615
eggNOG	1	0.900	-	-		E1_KOG1382
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I1856
OMA	1	1.010	-	-		QHG55377
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9257
orthoMCL	1	0.900	-	-		OOG6_101372
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.730