DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp1 and Minpp1

DIOPT Version :9

Sequence 1:	NP_001287082.1	Gene:	Mipp1 / 39841	FlyBaseID:	FBgn0026061	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_034929.1	Gene:	Minpp1 / 17330	MGIID:	1336159	Length:	481	Species:	Mus musculus

Alignment Length:	440	Identity:	115/440 - (26%)
Similarity:	190/440 - (43%)	Gaps:	66/440 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FSSKTAYQIVK--------GTDIDKQYLVPGCQPQKMWIFHRHGTRLPKKSMINKASRVAELRDL 89
            |.:||.|:...        ....|.:.|...|.|.::....|||||.|....|.|   :.:|:.|
Mouse    47 FGTKTRYEDANPWLLVDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRK---LKQLQGL 108

  Fly    90 IINNYQVARTKPETDALCQTDLIAIKLWKWNSSITPDMEEYLTAQGYEDLRGTAKLYQRYYPTVL 154
            :       :|:...|...|   :|..|.:|.......|:..|..:|.:|:|..|......:|.:.
Mouse   109 L-------QTRESRDGGSQ---VAAALAEWPLWYGDWMDGQLVEKGRQDMRQLALRLAALFPDLF 163

  Fly   155 TANYNDTYYQFR--HTDTQRTTESFKAFAEGLFGSQNAAHPVEIPKQDL-------------LLR 204
            :   .:.|.:.|  .:...|..:|..||.:||:   ...|| .:|..|:             |:|
Mouse   164 S---RENYDRLRLITSSKHRCVDSSAAFLQGLW---QHYHP-GLPPPDVSDMECGPPRINDKLMR 221

  Fly   205 PYDYCSSFKNVNYKDEGSEYY--KFHQSKLYNDTLADISTRLGFLYTLEEAD-IKLMYDMCRYEQ 266
            .:|:|..|.....::|.:.|:  .|.........|..::..|........|| |::.:..|.::.
Mouse   222 FFDHCEKFLTDVERNETALYHVEAFKTGPEMQKVLKKVAATLQVPMNSLNADLIQVAFFTCSFDL 286

  Fly   267 AWNVDRNSVWCGAFLPEQITVFEYLEDLKYYYGSGYGFPENAHLNCRLVQDLLTHL--------- 322
            |.. ..:|.||..|..:...|.|||.|||.|:...||:..|:..:|.|.||:..||
Mouse   287 AIK-GVHSPWCDVFDVDDARVLEYLNDLKQYWKRSYGYTINSRSSCNLFQDIFLHLDKAVEQKQR 350

  Fly   323 SNPVSPHVVAHFGHSTGLLTLLTALGIQKDDIKLRADNYDSLTSRRWKSSLIDPFAANFVAVKYD 387
            |.|||..|:..|||:..||.||:.:|..||...|.|.|::...:|:::|..|.|:|:|.:.|.|.
Mouse   351 SQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQVNRKFRSGHIVPYASNLIFVLYH 415

  Fly   388 C---PADLDREKVVFFLNQQAVQLDWCS--VGLCK-----WSDVLEKYKT 427
            |   .:..::.::...||::.:.|....  |||.:     :.|:|:..:|
Mouse   416 CDNAQSPEEQFQIQLLLNEKVLPLAHSQRPVGLYEELKTHYRDILQSCQT 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp1	NP_001287082.1	HP_HAP_like	129..402	CDD:132717	81/302 (27%)
Minpp1	NP_034929.1	HP_HAP_like	82..429	CDD:132717	98/367 (27%)
Minpp1	NP_034929.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	478..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1382
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5846
OMA	1	1.010	-	-		QHG55377
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004136
OrthoInspector	1	1.000	-	-		otm42375
orthoMCL	1	0.900	-	-		OOG6_101372
Panther	1	1.100	-	-	LDO	PTHR20963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.660