Protein Alignment LIMK1 and LRG1

DIOPT Version :10

• Sequence 1: NP_002305.1
• Gene: LIMK1 / 3984
• HGNCID: 6613
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_010041.2
• Gene: LRG1 / 851358
• SGDID: S000002399
• Length: 1017
• Species: Saccharomyces cerevisiae
• Alignment Length: 196
• Identity: 52/196 - (26%)
• Similarity: 76/196 - (38%)
• Gaps: 36/196 - (18%)

Human    24 VCASCGQRIY-DGQ----YLQALNADWHADCFRCCDCSASLSHQYY----EKDGQ--LFCKKDYW 77
            :||.|.:.:. |.|    .|:||...:|..||.|.||...|..:|:    :|..:  |.|:.||:
Yeast    27 ICARCNKLVIPDSQRTKTTLKALGKYYHESCFTCQDCQKPLKPKYFPYQVDKTSESILLCQYDYF 91

Human    78 ARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGT-------FIGDGDTYTLVEHSKLY-- 133
            .|:...||.|...: :||...|...:|..|.|.|..|.|       |:.....|......|.:
Yeast    92 RRHNLLCHVCDTPL-RGLYYTAFGYRYDEEHFSCTICATPCGVKKCFMYGNQLYCKYHFLKYFSK 155

Human   134 -CGHCYY----QTVVTPVIEQI---LPDSPGSH-------LPHTVTLVSIPASSHGKRGLSVSID 183
             |..|.:    |.:..|..|:|   .|:..|.|       ...||.|..:|...:........|:
Yeast   156 RCKGCEFPISDQYIEFPKGEEIHCWHPECYGIHKYWHVNLAAETVGLQYLPKLEYNPNSGDKDIN 220

Human   184 P 184
            |
Yeast   221 P 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846	20/63 (32%)
		LIM	84..138	CDD:413332	16/63 (25%)
		PDZ_LIMK-like	160..258	CDD:467236	6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..319
		STKc_LIMK1	345..611	CDD:271123
LRG1	NP_010041.2	LIM1_Lrg1p_like	28..90	CDD:188777	19/61 (31%)
		LIM	98..149	CDD:259829	14/51 (27%)
		LIM3_Lrg1p_like	419..475	CDD:188779
		RhoGAP_fLRG1	728..959	CDD:239862