Protein Alignment LIMK1 and limk1

DIOPT Version :10

• Sequence 1: NP_002305.1
• Gene: LIMK1 / 3984
• HGNCID: 6613
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_001072900.1
• Gene: limk1 / 780362
• XenbaseID: XB-GENE-1011258
• Length: 615
• Species: Xenopus tropicalis
• Alignment Length: 648
• Identity: 473/648 - (72%)
• Similarity: 526/648 - (81%)
• Gaps: 34/648 - (5%)

Human     1 MRLTLLCCTWREERMG-EEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYY 64
            |||.||||:|.||.|| |||:.|||||||||.||||.|||||..|||:|||||.||..||||:||
 Frog     1 MRLMLLCCSWSEEHMGEEEGNGLPVCASCGQSIYDGCYLQALALDWHSDCFRCSDCGVSLSHRYY 65

Human    65 EKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEH 129
            ||||:|||||.||||:|..|.||||.|||||||||||.|||||||:|..|..:|||.:||.|||.
 Frog    66 EKDGRLFCKKHYWARFGGMCQGCSENITKGLVMVAGEHKYHPECFMCSRCKAYIGDVETYALVER 130

Human   130 SKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTE 194
            ||||||.||||..|||||     |||||..||||||||:|||. |||||||||     .|.| .|
 Frog   131 SKLYCGPCYYQFSVTPVI-----DSPGSRSPHTVTLVSLPASD-GKRGLSVSI-----TPSC-AE 183

Human   195 HSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPH 259
            |||||||..:|..|:|||::::||:|||||||||||||:|||||||:||||||||||||:|||||
 Frog   184 HSHTVRVSQLDTDCLSPDIQSTIHIGDRILEINGTPIRSVPLDEIDVLIQETSRLLQLTIEHDPH 248

Human   260 DTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESL 324
                     ||..|.||.     ...:..||:|::||||||||||:..:|||:..|:|:.||||:
 Frog   249 ---------ETPTLPSPC-----TEITVRRQRPIMRSCSIDRSPGSSCVGSPSCSRRDMSRSESV 299

Human   325 RVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMR 389
            |.|...|||||||||:.|||||:||||||||||||.|||||||||||||||||||||||||||||
 Frog   300 RTVTGVHRIFRPSDLMPGEVLGRGCFGQAIKVTHRVTGEVMVMKELIRFDEETQRTFLKEVKVMR 364

Human   390 CLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 454
            |||||||||||||||||||||||||||.|||||.:|||||:.|||:||||||:|||:||.|||||
 Frog   365 CLEHPNVLKFIGVLYKDKRLNFITEYIPGGTLRRVIKSMDAHYPWNQRVSFARDIAAGMTYLHSM 429

Human   455 NIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 519
            ||||||||||||||||:.::||||||||||:.||      .|.|:| ||:|||||||||||||||
 Frog   430 NIIHRDLNSHNCLVREDGSLVVADFGLARLVTDE------TRDLRK-DRRKRYTVVGNPYWMAPE 487

Human   520 MINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITV 584
            |||||||||.|||||.|||:|||||||||||||||||||||||||.||||:|||||||.|||..|
 Frog   488 MINGRSYDESVDVFSCGIVICEIIGRVNADPDYLPRTMDFGLNVRAFLDRFCPPNCPPGFFPSAV 552

Human   585 RCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD 647
            .||||||||||.|.:|:.||::|..||...|||...||||:|.|||.||||:|.|..|||:|:
 Frog   553 LCCDLDPEKRPRFSQLQLWLDSLLRHLNLQLPLSSHLEQLERNFWENYRRGDSTLHVHPEIPE 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846	55/72 (76%)
		LIM	84..138	CDD:413332	39/53 (74%)
		PDZ_LIMK-like	160..258	CDD:467236	71/97 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..319		23/58 (40%)
		STKc_LIMK1	345..611	CDD:271123	219/265 (83%)
limk1	NP_001072900.1	LIM1_LIMK1	5..78	CDD:188846	55/72 (76%)
		LIM2_LIMK	85..139	CDD:188751	39/53 (74%)
		PDZ_LIMK-like	156..247	CDD:467236	71/97 (73%)
		Protein Kinases, catalytic domain	320..579	CDD:473864	219/265 (83%)