Protein Alignment LIMK1 and limk1a

DIOPT Version :10

• Sequence 1: NP_002305.1
• Gene: LIMK1 / 3984
• HGNCID: 6613
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_001036156.1
• Gene: limk1a / 735292
• ZFINID: ZDB-GENE-061212-3
• Length: 648
• Species: Danio rerio
• Alignment Length: 657
• Identity: 474/657 - (72%)
• Similarity: 532/657 - (80%)
• Gaps: 19/657 - (2%)

Human     1 MRLTLLCCTWREERMGEE--GSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQY 63
            |||.||||||::||||||  |..||||:.|||:|||.||||||::|||..|.|||:|.:||||.|
Zfish     1 MRLMLLCCTWKDERMGEEEAGVGLPVCSGCGQQIYDDQYLQALSSDWHTLCCRCCECGSSLSHWY 65

Human    64 YEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVE 128
            |||||:|||||||||::||.||||||.|:.||:|||||.|||||||.||:||.||||||||.|||
Zfish    66 YEKDGRLFCKKDYWAKFGELCHGCSEPISTGLIMVAGEQKYHPECFSCLSCGAFIGDGDTYALVE 130

Human   129 HSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGT 193
            .||||.|||||:::||||   .|||||.|.:||||||||||||:.||||.|||||....|.|...
Zfish   131 RSKLYSGHCYYRSIVTPV---SLPDSPCSRIPHTVTLVSIPASTDGKRGFSVSIDQASSPNGYSP 192

Human   194 EHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDP 258
            ||..||||..|.|.|:||||||||||||||||||||||:|||||||||||||||||||||:||||
Zfish   193 EHKRTVRVSQVYPDCISPDVKNSIHVGDRILEINGTPIQNVPLDEIDLLIQETSRLLQLTIEHDP 257

Human   259 HD---TLGH--GLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDL 318
            ||   ::.|  | ||..|...||...|..:..|:.|.:.:.||.|||:||.:.|..||.|.|||:
Zfish   258 HDQGPSVDHVDG-GPSPSGGPSPITRPPSQDISNLRSRIITRSYSIDKSPSSSSAPSPLSLRKDI 321

Human   319 GRSESLRVVC-RPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFL 382
            |||||||.|. |.|||||.||||||||||.|||||||||||||||||||||||||||||||||||
Zfish   322 GRSESLRGVSNRTHRIFRASDLIHGEVLGTGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFL 386

Human   383 KEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASG 447
            |||||||||:||||||||||||||||||||.|||||||||.|||:|||.|||.||||||||||||
Zfish   387 KEVKVMRCLDHPNVLKFIGVLYKDKRLNFIAEYIKGGTLRDIIKNMDSNYPWGQRVSFAKDIASG 451

Human   448 MAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGN 512
            |||||||||||||||||||||||||:||||||||:||||::::...     :|.||:||||||||
Zfish   452 MAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLSRLMVEDRSVER-----RKADRRKRYTVVGN 511

Human   513 PYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPP 577
            |||||||||:|:|||||||:|||||:|||||||||||||||||.:|||||...||:.:||.:||.
Zfish   512 PYWMAPEMIHGKSYDEKVDLFSFGIMLCEIIGRVNADPDYLPRALDFGLNTAVFLEEHCPADCPA 576

Human   578 SFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWE--TYRRGESGLP 640
            :||||...|||||.||||:|.|||.|||.|:|||...|.|..:||.|.:.|.:  |...|::.|.
Zfish   577 AFFPIAALCCDLDAEKRPAFTKLESWLEDLKMHLELGLHLVSELELLHQDFMQKHTSGGGKNSLH 641

Human   641 AHPEVPD 647
            .|||.|:
Zfish   642 THPEQPE 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846	53/73 (73%)
		LIM	84..138	CDD:413332	42/53 (79%)
		PDZ_LIMK-like	160..258	CDD:467236	77/97 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..319		25/63 (40%)
		STKc_LIMK1	345..611	CDD:271123	216/265 (82%)
limk1a	NP_001036156.1	LIM1_LIMK1	5..79	CDD:188846	53/73 (73%)
		LIM	86..140	CDD:413332	42/53 (79%)
		PDZ_LIMK-like	159..257	CDD:467236	77/97 (79%)
		STKc_LIMK1	349..610	CDD:271123	216/265 (82%)