Protein Alignment LIMK1 and LIMK1

DIOPT Version :10

• Sequence 1: NP_002305.1
• Gene: LIMK1 / 3984
• HGNCID: 6613
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 311/710 - (43%)
• Similarity: 409/710 - (57%)
• Gaps: 104/710 - (14%)

Human    19 GSELPVCASC-GQRI--YDGQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARY 80
            |...|:||.| ||.:  .:...:.||...||.|||||..|...|.:.|:|::|.|:|::||:.|:
  Fly    27 GGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCDCFRCSVCEGHLHNWYFEREGLLYCREDYYGRF 91

Human    81 GESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTP 145
            |::|..|...|| |.||||||.|:|||||.|..||:|||:|::|.|||.||||||.||.:....|
  Fly    92 GDACQQCMAVIT-GPVMVAGEHKFHPECFCCTACGSFIGEGESYALVERSKLYCGQCYGKRSCQP 155

Human   146 VIEQILPDSPGSHLPHTVTLVSIPA-SSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGV----- 204
            ...:....:.|..: |::.||.||. ::.|.|...|::|     .||     .|||:..:
  Fly   156 ADAKARITTAGKPM-HSIRLVEIPKDATPGLRVDGVALD-----DGC-----PTVRITDLFCNFF 209

Human   205 -------DPGCMSP---DVK-NSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDP 258
                   :..|.:|   ||. .::|:||||||:||||:.:..:::||.||:...::||||:||||
  Fly   210 LWLTSMAEQCCGAPYRIDVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVEHDP 274

Human   259 --------HDTLGHGLGPET--SPLSSPA----------YTPSGEAGSSARQKPVLRSCSIDRSP 303
                    ...:...:...|  .|||:.|          |...||.|:.||:.....:.|....|
  Fly   275 VQVCRSCSQADIQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKARKLRQATNASTTIPP 339

Human   304 GAGSLG--------------------------SPASQRKDLGRSESLRVVCRPHRIFRPSDLIHG 342
            .||:..                          |...|..||.|::|.|||.:|.||||.:||:.|
  Fly   340 AAGATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSRTQSCRVVQKPQRIFRATDLVIG 404

Human   343 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDK 407
            |.||:|.||:..|||||::|||||:|||.|.|||.||.|:|||.|:|.|:|.:||||||||||||
  Fly   405 EKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDK 469

Human   408 RLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENK 472
            :|:.:|||:.||.|:.:|.......||.|||..|:|||.||:||||||||||||||.||||||::
  Fly   470 KLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVREDR 534

Human   473 NVVVADFGLARLMVDEKTQPEG----------------------LRSLKKPDRKKRYTVVGNPYW 515
            :|:|||||||| .||....|.|                      ||..|...|::||||||||||
  Fly   535 SVIVADFGLAR-SVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVGNPYW 598

Human   516 MAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFF 580
            |||||:.|..||||||||||||:||||||||.||||::||..||.||.:.|.:::| ..||..|.
  Fly   599 MAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQEFREKFC-AQCPEPFV 662

Human   581 PITVRCCDLDPEKRPSFVKLEHWLETLRMHLAG-HLPLGPQLEQLDRGFWETYRRGESGL 639
            .:...||||:|:.||.|..|..||:.|...||. .:|....|.:::. |.|.|...|..|
  Fly   663 KVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPPERLLHEIET-FQEWYASSEDAL 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846	24/60 (40%)
		LIM	84..138	CDD:413332	34/53 (64%)
		PDZ_LIMK-like	160..258	CDD:467236	39/114 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..319		18/96 (19%)
		STKc_LIMK1	345..611	CDD:271123	163/287 (57%)
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750	23/57 (40%)
		LIM2_LIMK	95..148	CDD:188751	35/52 (67%)
		PDZ_LIMK-like	169..274	CDD:467236	41/129 (32%)
		STKc_LIMK	407..693	CDD:271056	137/264 (52%)