Protein Alignment LIMK1 and ksr-1

DIOPT Version :10

• Sequence 1: NP_002305.1
• Gene: LIMK1 / 3984
• HGNCID: 6613
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_509396.1
• Gene: ksr-1 / 181082
• WormBaseID: WBGene00002239
• Length: 771
• Species: Caenorhabditis elegans
• Alignment Length: 622
• Identity: 128/622 - (20%)
• Similarity: 216/622 - (34%)
• Gaps: 179/622 - (28%)

Human    84 CHGCSEQITKGLVMVAGELKYHPECFIC-----LTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVV 143
            ||.|...:..|.      |....:|..|     ..|...:||.            ||       :
 Worm   232 CHFCQRPLGFGF------LNAWEKCRSCKWKVHTQCKGRVGDS------------CG-------L 271

Human   144 TP-----VIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLS--------VSID-----------P 184
            ||     :.::::.::.|.       :...|.|..|.|.::        .:||           .
 Worm   272 TPDHLRFLFDKLIQENNGG-------MWKDPQSVPGSRSMNEPAFQFPDTAIDSSSSTNSSAPST 329

Human   185 PHGPPGCGTEHSHTVRVQGVDPGCMSPDVKN-SIHVGDRILEINGTPIRNVPLDEIDLLIQE--- 245
            |..|.|.....|........:...:.||.:| |:|        |..||         |:|.|
 Worm   330 PALPAGISGNVSSLTAPYRSERKFLFPDTENYSVH--------NRLPI---------LVISEGDH 377

Human   246 --TSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSS----ARQKPVLRSCSIDRSPG 304
              |:.:.|.|..|:                .|.|.:.||...|.    |..:....|..:|
 Worm   378 PTTTEIQQETENHN----------------KSAAASMSGNIESEGTIVANHEDSTGSQEVD---- 422

Human   305 AGSLGSPA-------SQRKDLG-----RSESLRVVCRPHRIFRPSDLI----------HGEVLGK 347
              |..:|:       ::|.|.|     .:.::..:..|:.....:::.          ...::|:
 Worm   423 --SEAAPSQEAVDKFNKRADGGFTWERHAWNMSTIRGPNAQASWNEVTIQFETIEFDKQAPIIGR 485

Human   348 GCFGQAIKVTHRETGEVMV---MKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRL 409
            |.||:.::..|  .|:|.|   ..|.|....:....|..||...:...|.|:..|:|....|.:.
 Worm   486 GRFGKVLRGFH--YGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQY 548

Human   410 NFITEYIKGG-TLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKN 473
            ..:....||. :|..::..:..:...:.....|:.|...::|||:..|:|:||.|.|.|:.....
 Worm   549 GMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNK 613

Human   474 VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW---MAPE--MINGRSYD------ 527
            ||:.|||:.           .::.|..|.:|..|  :.:.:|   :|||  |.....||
 Worm   614 VVITDFGIL-----------SMKRLAHPKQKSGY--LTSKFWTNYIAPELAMAMRTEYDEYECDD 665

Human   528 ----EKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPN--CPPSFFPITVRC 586
                |..||::||.|..|::.........||..:.|. ..:|.  |...||  |......:.|.|
 Worm   666 FPFSENSDVYAFGCVWFEMLTGALPYAGELPHQILFA-KTQGI--RPVLPNVKCTQELKELLVSC 727

Human   587 CDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQ 623
            .:..|:.||:       |..:.:.|.. ||..|::.:
 Worm   728 WNTAPQDRPT-------LTDINLKLTA-LPKKPRVNR 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846
		LIM	84..138	CDD:413332	12/58 (21%)
		PDZ_LIMK-like	160..258	CDD:467236	25/122 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..319		12/69 (17%)
		STKc_LIMK1	345..611	CDD:271123	70/286 (24%)
ksr-1	NP_509396.1	C1	216..269	CDD:197519	10/54 (19%)
		Protein Kinases, catalytic domain	482..751	CDD:473864	73/294 (25%)