Protein Alignment LIMK1 and lrk-1

DIOPT Version :10

• Sequence 1: NP_002305.1
• Gene: LIMK1 / 3984
• HGNCID: 6613
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_492839.4
• Gene: lrk-1 / 172995
• WormBaseID: WBGene00003068
• Length: 2393
• Species: Caenorhabditis elegans
• Alignment Length: 555
• Identity: 126/555 - (22%)
• Similarity: 191/555 - (34%)
• Gaps: 185/555 - (33%)

Human   145 PVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDP-GC 208
            |::|.:            |..:||.|:|...|.||:..|                 |:|... ..
 Worm  1515 PIVEMV------------VNSLSISAASQHGRKLSMKTD-----------------VEGRSRLLA 1550

Human   209 MSPDVKNSIHVGDRILE----INGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPE 269
            |..|:.      |.:||    ..||  |.|...|.|||:.......|..     .|...:|....
 Worm  1551 MISDLL------DTLLEDWYPALGT--RFVHSSEGDLLVSRYVLCPQCV-----RDAERNGSRSR 1602

Human   270 TSPLSSPAYTPSGEAG-----SSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVC- 328
            ||  ||.::..|.:.|     ||:..|....:..|.:..| |.:.....:...|...|...|.|
 Worm  1603 TS--SSASHRRSQDDGELPITSSSHMKGSRTTGDISKCRG-GVVHCFVIEECMLAGREYNWVECP 1664

Human   329 ----------RPHRIF---------RPSDLIHGEVLGKGCFGQAIKVTHRE-TGEVMVM------ 367
                      .|..:|         .|..|....:||:|.||...:.|.|: .||:..:
 Worm  1665 SHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLE 1729

Human   368 ------------------------KELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKR 408
                                    ::.:.|......|..:|:.::..::||||:..:||.  ...
 Worm  1730 PVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVC--TFP 1792

Human   409 LNFITEYIKGGTLR---------------GIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 458
            |:.:.|....|.|.               |:||..            |..:|..:.||||.:||:
 Worm  1793 LSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKES------------AVQVARALEYLHSAHIIY 1845

Human   459 RDLNSHNCL---------VRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 514
            |||.|.|.|         .:.:..:.:.|:|::|.::     |.|        ..|.:.  |...
 Worm  1846 RDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVL-----PSG--------GAKGFG--GTEG 1895

Human   515 WMAPEMI--NG-RSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLN-----VRGFLDRYC 571
            :||||::  || ..|.:|||.||||:.|.|::            |:.|...     ....||...
 Worm  1896 FMAPEIVRFNGEEEYTQKVDCFSFGMFLYELL------------TLKFPFESEEHVKERMLDGAR 1948

Human   572 P---PN---CPPSFFPITVRCCDLDPEKRPSFVKL 600
            |   |:   .|.....:.|.|....||.|||..:|
 Worm  1949 PVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQL 1983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846
		LIM	84..138	CDD:413332
		PDZ_LIMK-like	160..258	CDD:467236	25/102 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..319		14/63 (22%)
		STKc_LIMK1	345..611	CDD:271123	77/325 (24%)
lrk-1	NP_492839.4	ANKYR	13..337	CDD:440430
		ANK repeat	56..88	CDD:293786
		ANK repeat	90..121	CDD:293786
		ANK repeat	197..228	CDD:293786
		ANK repeat	230..262	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	366..472	CDD:463710
		ANK repeat	398..432	CDD:293786
		LRR	<529..>778	CDD:443914
		leucine-rich repeat	534..555	CDD:275380
		leucine-rich repeat	556..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..627	CDD:275380
		leucine-rich repeat	628..654	CDD:275380
		leucine-rich repeat	655..684	CDD:275380
		leucine-rich repeat	687..718	CDD:275380
		leucine-rich repeat	719..742	CDD:275380
		leucine-rich repeat	743..765	CDD:275380
		leucine-rich repeat	803..856	CDD:275380
		LRR	<857..>953	CDD:443914
		leucine-rich repeat	857..883	CDD:275380
		leucine-rich repeat	884..906	CDD:275380
		leucine-rich repeat	907..931	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	977..1160	CDD:476819
		COR	<1239..>1336	CDD:406489
		Protein Kinases, catalytic domain	1699..1990	CDD:473864	77/326 (24%)