DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and PDR10

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_014973.1	Gene:	PDR10 / 854506	SGDID:	S000005855	Length:	1564	Species:	Saccharomyces cerevisiae

Alignment Length:	773	Identity:	210/773 - (27%)
Similarity:	330/773 - (42%)	Gaps:	170/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDSDSKRIDVEAPER--------VEQHELQVMPVGSTIEVPSLDSTPKLSKRNSSERSLPLRSY 57
            :|.||::: |||....        :...:..:|....|:..... |:|..|...|:       |:
Yeast   853 LSTSDAEK-DVEMNNNSSATDSRFLRDSDAAIMGNDKTVAKEHY-SSPSSSASQSN-------SF 908

  Fly    58 SKWSPTE---QGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMS 119
            ||....|   ..|...|::|| |.....:|:|  ||::|..|.::||||.||:|:||:|||||:.
Yeast   909 SKSDDIELSKSQAIFHWKNLC-YDIPIKNGKR--RILDNVDGWVKPGTLTALIGASGAGKTTLLD 970

  Fly   120 TLAFRQPAGTVVQGDILINGRRIGPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKE 184
            .||.|...| ::.||:.::||.......|..||..|.||.|.:.||.|.|.|.|:||....||.|
Yeast   971 CLAERTTMG-LITGDVFVDGRPRDQSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQADDVSIE 1034

  Fly   185 ERRLIIKELLERTGLLSAAQTRIG-SGDDKKVLSGGERKRLAFAVELLNNP-VILFCDEPTTGLD 247
            |:...::|::|...:...|...:| .|:.   |:..:||||...|||...| :::|.||||:|||
Yeast  1035 EKDKYVEEVIEVLEMKLYADAIVGVPGEG---LNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLD 1096

  Fly   248 SYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLLAD-GRVAFTG----SPQHALSFF 307
            |.:|......:.:||.:|..|||||||||:.|...|:.::.|.: |:..:.|    ..:..:::|
Yeast  1097 SQTAWSTCQLMKKLASRGQAILCTIHQPSALLMQEFDRLLFLQEGGQTVYFGELGKGCKTMINYF 1161

  Fly   308 ANHG-YYCPEAYNPADFLIGVLATDPGYEQASQRSAQHLCDQFAV-SSAAKQRDMLVNL-----E 365
            ..|| :.||...|||::::.::...|| ..|||       |.||: ..:.:.|:|...|     |
Yeast  1162 EAHGAHKCPPDANPAEWMLEIVGAAPG-THASQ-------DYFAIWRDSEEYREMQKELDWMERE 1218

  Fly   366 IHMAQSGNFPFDTEVESFR-------GVAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAFI 423
            :.....|:  .:.|.:.|.       .:..|:.||..|        |.|...|.:|...|.....
Yeast  1219 LPKRTEGS--SNEEQKEFATSTLYQIKLVSYRLFHQYW--------RTPFYLWSKFFSTIVSELF 1273

  Fly   424 IGACF--AGTTEPSQLGVQAVQGALFIMISENTYHPMYSVL--NLFPQGFPLFM--------RET 476
            ||..|  |.|   |..|:|....|:|          |::|:  .:..|..|||:        ||.
Yeast  1274 IGFTFFKANT---SLQGLQNQMLAIF----------MFTVVFNPILQQYLPLFVQQRELYEARER 1325

  Fly   477 RSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGL-RSTFYA------------------- 521
            .|..:|...:..:.||..:|..::...|...:.|:..|. |:..||
Yeast  1326 PSRTFSWKAFIVSQILVEIPWNLLAGTIAFFVYYYPVGFYRNASYANQLHERGALFWLFACAFYV 1390

  Fly   522 ----FGVTAM-CVVLVMNVATACGCFF--STAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPV 579
                .||..: |:.:..|.|.....||  |.:|..| ||...::|..:|||....        |:
Yeast  1391 YISSMGVLVISCIEIAENAANLASLFFIMSLSFCGV-LATPNILPRFWIFMYRVS--------PL 1446

  Fly   580 AFWWTQFLSWML-------YANEAMTAAQWSGVQNITC--FQE--------------SADLPC-- 619
            .:.....||..|       .:||.:.....||   :||  :.|              |::..|
Yeast  1447 TYLIDALLSVGLANASVVCSSNELLKIVPPSG---MTCSEYMEPYMQSTGTGYLLDGSSETECHF 1508

  Fly   620 --FHTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGY----YCLW-----RRARKL 666
              |.:..|.|...|.:.|..:.|    .|::..:.:..|    :..|     ::::||
Yeast  1509 CQFSSTNDYLATVSSSYSRRWMN----YGIFSAYIVFDYCAAIFLYWLVRVPKKSKKL 1562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	92/234 (39%)
		3a01204	67..665	CDD:273361	192/693 (28%)
		ABC2_membrane	395..600	CDD:279410	57/250 (23%)
PDR10	NP_014973.1	3a01205	110..1556	CDD:273362	208/765 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	1	0.960	-	-
	4	3.890