DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and PDR5

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_014796.3	Gene:	PDR5 / 854324	SGDID:	S000005679	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	722	Identity:	197/722 - (27%)
Similarity:	311/722 - (43%)	Gaps:	152/722 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EVPSLDSTPKLSKRNSSERSLPLRSYSKWSPTEQGATLVWRDLCVYTNVGGSGQRMKRIINNSTG 96
            |...|.|..|:.:.:|.|.|   .:|.:...::..|...||:||....:..   ..:||:||..|
Yeast   835 ERSDLSSDRKMLQESSEEES---DTYGEIGLSKSEAIFHWRNLCYEVQIKA---ETRRILNNVDG 893

  Fly    97 AIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHRISGYVYQDDLFLG 161
            .::||||.||||:||:|||||:..||.|...| |:.||||:||........|..||..|.||.|.
Yeast   894 WVKPGTLTALMGASGAGKTTLLDCLAERVTMG-VITGDILVNGIPRDKSFPRSIGYCQQQDLHLK 957

  Fly   162 SLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIG-SGDDKKVLSGGERKRLA 225
            :.||.|.|.|.|:||....||.||:...::|:::...:...|...:| :|:.   |:..:||||.
Yeast   958 TATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAGEG---LNVEQRKRLT 1019

  Fly   226 FAVELLNNP-VILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLL 289
            ..|||...| :::|.||||:||||.:|..:...:.:||..|..|||||||||:.|...|:.::.:
Yeast  1020 IGVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFM 1084

  Fly   290 -ADGRVAFTG----SPQHALSFFANHG-YYCPEAYNPADFLIGVLATDPG------YEQASQRSA 342
             ..|:..:.|    ..:..:.:|.:|| :.||...|||::::.|:...||      |.:..:.|.
Yeast  1085 QRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQDYYEVWRNSE 1149

  Fly   343 QHLCDQFAVSSAA--KQRDMLVNLEIHMAQ-----SGNFPFDTEVESFRGVAWYKRFHVVWLRAS 400
            ::.    ||.|..  .:|::.....|..|:     |.:..:.|::.|.|      .|...|
Yeast  1150 EYR----AVQSELDWMERELPKKGSITAAEDKHEFSQSIIYQTKLVSIR------LFQQYW---- 1200

  Fly   401 LTLLRDPTIQWLRFIQKIAMAFIIGACF--AGTTEPSQLGVQAVQGALFIMISENTYHPMYSVL- 462
                |.|...|.:||..|.....||..|  |||   |..|:|....|:|          |::|:
Yeast  1201 ----RSPDYLWSKFILTIFNQLFIGFTFFKAGT---SLQGLQNQMLAVF----------MFTVIF 1248

  Fly   463 -NLFPQGFPLFM--------RETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRS- 517
             .:..|..|.|:        ||..|..:|...:..|.|...:|..|:...|...|.|:..|..|
Yeast  1249 NPILQQYLPSFVQQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTIAYFIYYYPIGFYSN 1313

  Fly   518 -------------------TFYAFGVTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYI 563
                               .||.: |.:|.::::             :||.|..:.|.|..|.:.
Yeast  1314 ASAAGQLHERGALFWLFSCAFYVY-VGSMGLLVI-------------SFNQVAESAANLASLLFT 1364

  Fly   564 FMIT-SGIFIQVNSLPVAFWWTQF-LSWMLYANEAMTAAQWSGVQN--ITC-------FQESADL 617
            ..:: .|:....:::| .||...: :|.:.|..:|:.|.   ||.|  :.|       |...:.:
Yeast  1365 MSLSFCGVMTTPSAMP-RFWIFMYRVSPLTYFIQALLAV---GVANVDVKCADYELLEFTPPSGM 1425

  Fly   618 PC--------------FHTGQDVLDKYSFNESNVYRNLLAMVG--------------LYFGF-HL 653
            .|              :.|.::..|..||.:.:...:.||.|.              .|..| ::
Yeast  1426 TCGQYMEPYLQLAKTGYLTDENATDTCSFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYI 1490

  Fly   654 LGYYCLW 660
            .|.:..|
Yeast  1491 AGVFFYW 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	93/234 (40%)
		3a01204	67..665	CDD:273361	189/687 (28%)
		ABC2_membrane	395..600	CDD:279410	53/238 (22%)
PDR5	NP_014796.3	ABC_trans_N	46..152	CDD:405234
PDR5	NP_014796.3	3a01205	100..1503	CDD:273362	197/722 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	1	0.960	-	-
	5	4.800