DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and AUS1

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_014654.1	Gene:	AUS1 / 854175	SGDID:	S000005537	Length:	1394	Species:	Saccharomyces cerevisiae

Alignment Length:	768	Identity:	189/768 - (24%)
Similarity:	306/768 - (39%)	Gaps:	189/768 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDSKRIDVEAPERVEQHELQVMPVGSTIEVPSLDSTP-KLSKRNSSERSLPLRSYSKWSPTE--- 64
            :|||.:.:.....|....            .||.:.| ::|..|   :.:.|..|::...||
Yeast   696 NDSKYVGIPKSHSVSSSS------------SSLSAVPYQISPSN---KEMALNDYNEQPITETVE 745

  Fly    65 -QGATLVWRDLCVYTNVGGSGQRMKRIINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAG 128
             |...:.|::: .|| ||     .|::|||::|.|..| |.||||.||:|||||::.|:.|...|
Yeast   746 TQKHIISWKNI-NYT-VG-----TKKLINNASGFISSG-LTALMGESGAGKTTLLNVLSQRVETG 802

  Fly   129 TVVQGDILINGRRI---GPFMHRISGYVYQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLI- 189
             ||.|:|||:|..:   ..|...| |:|.|.||.|..|:|.|.|.....||.|     .:|..:
Yeast   803 -VVSGEILIDGHPLTDEDAFKRSI-GFVQQQDLHLDLLSVKESLEISCLLRGD-----GDRAYLD 860

  Fly   190 -IKELLERTGLLSAAQTRIGSGDDKKVLSGGERKRLAFAVELLNNP-VILFCDEPTTGLDSYSAQ 252
             :..||:....:..|.           |:..:||.|:..|||:..| ::||.||||:|||:.:|.
Yeast   861 TVSNLLKLPSDILVAD-----------LNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAAL 914

  Fly   253 QLVATLYELAQKGTTILCTIHQPSSQLFDNFNNVMLL-ADGRVAFTGSPQHALSFFANHG---YY 313
            .:|..|.:|:.:|..|.|||||||..:..:|:|:.|| ..|...|.|....|..:|.:|.   .|
Yeast   915 TIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVY 979

  Fly   314 CPEAYNPADFLIGVLA---TDPGYEQASQRSA--QHLCDQFAVSSAAKQRDML----VNLEIHMA 369
            ..|..|||||:|..:.   :..|.:.|.:...  :...|..|:..::.::.::    ..||....
Yeast   980 DKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDAR 1044

  Fly   370 QSGNFPFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTIQWLRFIQKIAMAFIIGACFAGTTEP 434
            .||   .|.....::..::.::..::..|..:...||.|....::            |..|
Yeast  1045 ASG---VDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKY------------CLNG---- 1090

  Fly   435 SQLGVQAVQGA-LFIMISENTYHPMYSVLNLFPQGFPLFM------------------------- 473
                     || |||..|  .:|..::::.|....|..||
Yeast  1091 ---------GAGLFIGFS--FWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVA 1144

  Fly   474 RETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATA 538
            ||.||..|.......:..:..||..:....:|.:..::..|..:..::.||..:..:|
Yeast  1145 REARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYML------- 1202

  Fly   539 CGCFFSTAFNSVPLAMAYLVP--------LDYIFMITSGI--FIQVNSLPVAFW--------WTQ 585
                |:..::::.|.:.|..|        :.:|:..|:..  .:|..||...||        :|.
Yeast  1203 ----FAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTY 1263

  Fly   586 FL---------SWMLYAN-------------------EAMTAAQWSGVQNITCFQESADLPCFHT 622
            |:         :|.:..:                   ||........:.|...|...|  .|.:|
Yeast  1264 FVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCA--YCTYT 1326

  Fly   623 -GQDVLDKYSFNESNVYRNL---LAMVGLYFGFHLLGYYC-----LWRRARKL 666
             |.|.|...:.:..:|:||.   .|.||..|.....|||.     :|.:..|:
Yeast  1327 VGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKI 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	89/238 (37%)
		3a01204	67..665	CDD:273361	174/697 (25%)
		ABC2_membrane	395..600	CDD:279410	45/276 (16%)
AUS1	NP_014654.1	3a01205	56..1369	CDD:273362	187/756 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	2.930