DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment st and ABCG8

DIOPT Version :9

Sequence 1:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_200098.1	Gene:	ABCG8 / 835363	AraportID:	AT5G52860	Length:	589	Species:	Arabidopsis thaliana

Alignment Length:	602	Identity:	164/602 - (27%)
Similarity:	267/602 - (44%)	Gaps:	91/602 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IINNSTGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVVQGDILINGRRIGPFMHR-ISGYV 153
            |:.|.|....|..::|::|.||:||:||:..||.:.   :...|.||:|...|.|..:| ||.||
plant    44 ILRNITLTAHPTEILAVVGPSGAGKSTLLDILASKT---SPTSGSILLNSIPINPSSYRKISSYV 105

  Fly   154 YQDDLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSG 218
            .|.|.|...|||.|..:|.|.|.|.......|   .:..||....|...:.||:..|     |||
plant   106 PQHDSFFPLLTVSETFSFAACLLLPNPSIVSE---TVTSLLSELNLTHLSHTRLAQG-----LSG 162

  Fly   219 GERKRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELA-QKGTTILCTIHQPSSQLFDN 282
            |||:|::..:.||::|..|..||||:||||.||..::..|..:| .:..|::.:|||||.::...
plant   163 GERRRVSIGLSLLHDPCFLLLDEPTSGLDSKSAFDVIHILKSIAVSRQRTVILSIHQPSFKILSI 227

  Fly   283 FNNVMLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLA--------TD----PGYE 335
            .:.::||:.|.|.:.|.......|....|:..|...|..::.:.:|.        ||    |..|
plant   228 IDRLLLLSKGTVVYHGRLDSLEGFLLFKGFTVPPQLNSLEYAMEILQELRESDGNTDATALPSIE 292

  Fly   336 QASQRSAQHLCDQFAVSSAAKQRDMLVNLEIHMAQSGNFPFDTEVESFRGVAWYKRFHVVWLRAS 400
            ...||..|         |..:.|...:               ||:....     :||..:..|..
plant   293 NRKQREKQ---------SIVRYRKSRI---------------TEISLLA-----RRFWKIIYRTR 328

  Fly   401 LTLLRDPTIQWLRFIQKIAMAFIIGACF-------AGTTEPSQLGVQAVQGALFIMISENTYHPM 458
            ..||.:.       ::.:.:..::|..:       ||..:  :.|:.|.  .|..::|..|
plant   329 QLLLTNA-------LEALVVGLVLGTIYINIGIGKAGIEK--RFGMFAF--TLTFLLSSTT---- 378

  Fly   459 YSVLNLFPQGFPLFMRETRSGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFG 523
             ..|.:|....|:.:|||.||:|....:..||.|..||.:.:..:|:.:..|:|.||..|:.|||
plant   379 -ETLPIFINERPILLRETSSGIYRLSSHILANTLVFLPYLFVISIIYSVSVYFLIGLCPTWQAFG 442

  Fly   524 VTAMCVVLVMNVATACGCFFSTAFNSVPLAMAYLVPLDYI------FMITSGIFIQVNSLPVAFW 582
            ...:.:.:::.:|.:...|.|:      ||..|:.....:      |.:.||.||...|||..:.
plant   443 YFVLVIWIILLMANSFVLFLSS------LAPNYITGTSLVTILLAAFFLFSGYFISKESLPKYWL 501

  Fly   583 WTQFLSWMLYANEAMTAAQWSGVQN--ITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAMV 645
            :..|.|...||.:|:...::|.:.:  :...:|:....|..||.|||.|...:|...:.|:..::
plant   502 FMYFFSMYKYALDALLINEYSCLASKCLVWLEEAQTKICMVTGGDVLKKKGLHEKQRWFNVYVLL 566

  Fly   646 GLYFGFHLLGYYCLWRR 662
            |.:..:.:|.:..|.||
plant   567 GFFVLYRVLCFLALLRR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	76/209 (36%)
		3a01204	67..665	CDD:273361	164/602 (27%)
		ABC2_membrane	395..600	CDD:279410	53/217 (24%)
ABCG8	NP_200098.1	P-loop_NTPase	29..243	CDD:304359	76/209 (36%)
		3a01204	44..584	CDD:273361	164/602 (27%)
		ABC2_membrane	316..519	CDD:279410	55/229 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880